New approach to assembling nucleic acid dendrons on a solid phase
New approach to assembling nucleic acid dendrons on a solid phase
We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5′-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.
9500-9505
Chik, Gerald J.
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El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
29 August 2025
Chik, Gerald J.
8cd88cd1-9723-4638-ab46-8f09a50b1d86
El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Chik, Gerald J., El-Sagheer, Afaf H. and Brown, Tom
(2025)
New approach to assembling nucleic acid dendrons on a solid phase.
Organic Letters, 27 (34), .
(doi:10.1021/acs.orglett.5c02877).
Abstract
We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5′-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.
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Accepted/In Press date: 15 August 2025
e-pub ahead of print date: 20 August 2025
Published date: 29 August 2025
Identifiers
Local EPrints ID: 506195
URI: http://eprints.soton.ac.uk/id/eprint/506195
ISSN: 1523-7060
PURE UUID: ca50b684-efa2-4292-ad03-252ffecc42bf
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Date deposited: 30 Oct 2025 17:32
Last modified: 31 Oct 2025 02:39
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Author:
Gerald J. Chik
Author:
Afaf H. El-Sagheer
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