A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials
Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.
Potter, Shelly
9c6d05fe-bcb0-4f20-99ed-1de3cb90a164
Avery, Kerry
4c062556-694b-4feb-a356-5cae1be8024a
Ahmed, Rosina
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Savva, Constantinos
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28 October 2025
Potter, Shelly
9c6d05fe-bcb0-4f20-99ed-1de3cb90a164
Avery, Kerry
4c062556-694b-4feb-a356-5cae1be8024a
Ahmed, Rosina
a0b2caa1-b2d0-44a4-a2c3-d1a4730c0c58
Savva, Constantinos
d6e87674-1443-41f4-84ba-81c1ccfeb3d7
Potter, Shelly, Avery, Kerry and Ahmed, Rosina
,
et al. and PRECEDENT Study Group
(2025)
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials.
npj Breast Cancer, 11, [116].
(doi:10.1038/s41523-025-00824-w).
Abstract
Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.
Text
s41523-025-00824-w
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Accepted/In Press date: 21 August 2025
e-pub ahead of print date: 28 August 2025
Published date: 28 October 2025
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Local EPrints ID: 506303
URI: http://eprints.soton.ac.uk/id/eprint/506303
ISSN: 2374-4677
PURE UUID: 0d9b9e25-1255-46f2-b620-268c7d1e5af4
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Date deposited: 04 Nov 2025 17:32
Last modified: 08 Nov 2025 02:57
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Contributors
Author:
Shelly Potter
Author:
Kerry Avery
Author:
Rosina Ahmed
Corporate Author: et al.
Corporate Author: PRECEDENT Study Group
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