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Novel approaches to the stratified management of knee osteoarthritis

Novel approaches to the stratified management of knee osteoarthritis
Novel approaches to the stratified management of knee osteoarthritis
Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presentation, including co-morbidity and pain phenotype, can influence treatment decisions, and there is a rich history of imaging biomarker use, both from conventional radiographs and, since its development, via MRI, in identifying patients at risk of disease progression, and the latter facilitates the detection of synovitis. The development of novel biochemical biomarkers and the rapid growth of ‘-omics’ technologies provide fresh opportunities to deploy these advances in the stratification of patients with knee osteoarthritis. The health economic landscape in this area is developing, and scoping work has highlighted the need for further studies.
1759-4790
684–695
Fuggle, Nicholas R.
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Chapurlat, Roland
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Laslop, Andrea
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Al-Daghri, Nasser M.
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Alokail, Majed S.
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Thiyagarajan, Jotheeswaran Amuthavalli
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Balkowiec-Iskra, Ewa
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Berenbaum, Francis
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Bemden, Angie Botto-van
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Borg, John-Joseph
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Bruyere, Olivier
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Burlet, Nansa
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Cavalier, Etienne
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Rosa, Mario M.
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Conaghan, Philip G.
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Cooper, Cyrus
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Dennison, Elaine
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Englund, Martin
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Im, Gun-il
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Haugen, Ida K.
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Hiligsmann, Mickaël
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Kurth, Andreas
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Lane, Nancy E.
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Lories, Rik J.
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Marlovits, Stefan
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Matijevic, Radmila
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Mobasheri, Ali
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Ormarsdottir, Sif
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Prieto Yerro, Maria C.
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Radermecker, Regis P.
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Rannou, François
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Sepodes, Bruno
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Harvey, Nicholas C.
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Fuggle, Nicholas R.
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Chapurlat, Roland
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Laslop, Andrea
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Al-Daghri, Nasser M.
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Alokail, Majed S.
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Thiyagarajan, Jotheeswaran Amuthavalli
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Balkowiec-Iskra, Ewa
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Berenbaum, Francis
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Bemden, Angie Botto-van
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Borg, John-Joseph
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Bruyere, Olivier
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Burlet, Nansa
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Cavalier, Etienne
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Rosa, Mario M.
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Conaghan, Philip G.
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Cooper, Cyrus
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Dennison, Elaine
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Englund, Martin
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Im, Gun-il
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Haugen, Ida K.
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Hiligsmann, Mickaël
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Kurth, Andreas
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Lane, Nancy E.
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Lories, Rik J.
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Marlovits, Stefan
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Matijevic, Radmila
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Mobasheri, Ali
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Ormarsdottir, Sif
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Prieto Yerro, Maria C.
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Radermecker, Regis P.
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Rannou, François
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Sepodes, Bruno
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Harvey, Nicholas C.
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Fuggle, Nicholas R., Chapurlat, Roland, Laslop, Andrea, Al-Daghri, Nasser M., Alokail, Majed S., Thiyagarajan, Jotheeswaran Amuthavalli, Balkowiec-Iskra, Ewa, Berenbaum, Francis, Bemden, Angie Botto-van, Borg, John-Joseph, Bruyere, Olivier, Burlet, Nansa, Cavalier, Etienne, Rosa, Mario M., Conaghan, Philip G., Cooper, Cyrus, Dennison, Elaine, Englund, Martin, Im, Gun-il, Haugen, Ida K., Hiligsmann, Mickaël, Kurth, Andreas, Lane, Nancy E., Lories, Rik J., Marlovits, Stefan, Matijevic, Radmila, Mobasheri, Ali, Ormarsdottir, Sif, Prieto Yerro, Maria C., Radermecker, Regis P., Rannou, François, Sepodes, Bruno and Harvey, Nicholas C. (2025) Novel approaches to the stratified management of knee osteoarthritis. Nature Reviews Rheumatology, 21, 684–695. (doi:10.1038/s41584-025-01305-x).

Record type: Article

Abstract

Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presentation, including co-morbidity and pain phenotype, can influence treatment decisions, and there is a rich history of imaging biomarker use, both from conventional radiographs and, since its development, via MRI, in identifying patients at risk of disease progression, and the latter facilitates the detection of synovitis. The development of novel biochemical biomarkers and the rapid growth of ‘-omics’ technologies provide fresh opportunities to deploy these advances in the stratification of patients with knee osteoarthritis. The health economic landscape in this area is developing, and scoping work has highlighted the need for further studies.

Text
NRR-24-162V3_final au queries_NRF - Final - Accepted Manuscript
Restricted to Repository staff only until 3 April 2026.
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Accepted/In Press date: 5 September 2025
e-pub ahead of print date: 3 October 2025
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Identifiers

Local EPrints ID: 506340
URI: http://eprints.soton.ac.uk/id/eprint/506340
DOI: doi:10.1038/s41584-025-01305-x
ISSN: 1759-4790
PURE UUID: 26881375-5394-424b-a5c9-44c7e6ce48af
ORCID for Nicholas R. Fuggle: ORCID iD orcid.org/0000-0001-5463-2255
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 04 Nov 2025 18:10
Last modified: 05 Nov 2025 02:56

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Contributors

Author: Nicholas R. Fuggle ORCID iD
Author: Roland Chapurlat
Author: Andrea Laslop
Author: Nasser M. Al-Daghri
Author: Majed S. Alokail
Author: Jotheeswaran Amuthavalli Thiyagarajan
Author: Ewa Balkowiec-Iskra
Author: Francis Berenbaum
Author: Angie Botto-van Bemden
Author: John-Joseph Borg
Author: Olivier Bruyere
Author: Nansa Burlet
Author: Etienne Cavalier
Author: Mario M. Rosa
Author: Philip G. Conaghan
Author: Cyrus Cooper ORCID iD
Author: Elaine Dennison ORCID iD
Author: Martin Englund
Author: Gun-il Im
Author: Ida K. Haugen
Author: Mickaël Hiligsmann
Author: Andreas Kurth
Author: Nancy E. Lane
Author: Rik J. Lories
Author: Stefan Marlovits
Author: Radmila Matijevic
Author: Ali Mobasheri
Author: Sif Ormarsdottir
Author: Maria C. Prieto Yerro
Author: Regis P. Radermecker
Author: François Rannou
Author: Bruno Sepodes
Author: Nicholas C. Harvey ORCID iD

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