Impact of a High Fat Meal Combined with Prolonged Sitting on Central and Peripheral Arterial Stiffness; A Pilot Study: 2447 Board# 111 May 31 11: 00 AM-12: 30 PM

Abstract

Acute sedentary behavior, such as prolonged sitting, has a detrimental impact upon markers of central and peripheral arterial health, including arterial stiffness. Similarly, a high-fat meal can also negatively impact post-prandial measures of central and systemic arterial stiffness. However, the interaction between prolonged sitting and high-fat meal consumption and its effects on central and peripheral arterial health has not been investigated.

PURPOSE: To determine the effects of 3 hours of prolonged sitting, with and without a high fat meal on central and peripheral arterial stiffness.

METHODS: Five young healthy males (Age: 22.8±2.5 yrs, BMI: 25±4.4 kg/m2), from a target of 18, have been recruited. Following familiarization, participants visited the laboratory on two occasions and completed a 3 hour period of prolonged sitting following the consumption either a high-fat (HF) or low-fat (CON) meal, in a randomized order. Visits were separated by a minimum of 2, and maximum of 7 days. Before and after prolonged sitting, supine central (carotid-femoral pulse-wave velocity [cfPWV]) and peripheral (femoral-ankle pulse-wave velocity [faPWV]) arterial stiffness were measured. High (60g of fat) and CON (10 g of fat) meals were matched for macronutrient content and volume. Data was analyzed using two-way repeated measures analysis of variance. Alpha was set at P < 0.1 a priori for preliminary analyses.

RESULTS: A significant interaction effect was observed for cfPWV (Group x Time, P = 0.079); post hoc analysis revealed that cfPWV increased following HF (Pre = 5.7±0.6 m/s vs. Post = 6.1±.06; p<0.05, η2P=0.71) but was unchanged following CON (Pre = 6.2±0.8 m/s vs. Post = 6.2±0.6; p>0.05, η2P=0.016). No interaction (P = 0.643) or group (P = 0.175) effect was observed for faPWV, but faPWV did significantly decrease following sitting (Pre = 9.7±0.4 m/s vs. Post = 8.9±0.5; p<0.05, η2P=0.641).

CONCLUSIONS: The preliminary findings of this study suggest that, in young healthy adults, a high-fit meal, in combination with prolonged sitting may lead to a greater increase in central arterial stiffness than sitting combined with a low fat meal. Further, prolonged sitting may differentially impact central and peripheral arterial stiffness.

More information

Identifiers

ORCID for James Faulkner: orcid.org/0000-0002-3704-6737

Catalogue record

Export record

Altmetrics