Antibiotic resistance mechanisms and their transmission in Acinetobacter baumannii
Antibiotic resistance mechanisms and their transmission in Acinetobacter baumannii
The discovery of penicillin over 90 years ago and its subsequent uptake by healthcare systems around the world revolutionised global health. It marked the beginning of a golden age in antibiotic discovery with new antibiotics readily discovered from natural sources and refined into therapies that saved millions of lives. Towards the end of the last century, the rate of discovery slowed to a near standstill. The lack of discovery is compounded by the rapid emergence and spread of bacterial pathogens that exhibit resistance to multiple antibiotic therapies and threaten the sustainability of global healthcare systems. Acinetobacter baumannii is an opportunistic pathogen whose prevalence and impact has grown significantly over the last 20 years. It is recognised as a barometer of the antibiotic resistance crisis due to the diverse array of mechanisms by which it can become resistant.
Acinetobacter baumannii, Anti-Bacterial Agents/pharmacology, Bacteria, Drug Resistance, Multiple, Bacterial/genetics
135-153
McCarthy, Ronan R.
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Larrouy-Maumus, Gerald J.
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Meiqi Tan, Mei Gei C.
126bbd30-9695-44b7-b83d-7772bc1e92f2
Wareham, David W.
f6a1ae78-15a8-4869-91df-55a4eddf2904
19 October 2021
McCarthy, Ronan R.
0b2cf2e0-b0ff-4c92-aa04-92d91182d1f2
Larrouy-Maumus, Gerald J.
6e4e5c7d-be07-49a8-af51-318157d37bc6
Meiqi Tan, Mei Gei C.
126bbd30-9695-44b7-b83d-7772bc1e92f2
Wareham, David W.
f6a1ae78-15a8-4869-91df-55a4eddf2904
McCarthy, Ronan R., Larrouy-Maumus, Gerald J., Meiqi Tan, Mei Gei C. and Wareham, David W.
(2021)
Antibiotic resistance mechanisms and their transmission in Acinetobacter baumannii.
In,
Kishore, U.
(ed.)
Microbial Pathogenesis.
(Advances in Experimental Medicine and Biology, 1313)
Springer Cham, .
(doi:10.1007/978-3-030-67452-6_7).
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Abstract
The discovery of penicillin over 90 years ago and its subsequent uptake by healthcare systems around the world revolutionised global health. It marked the beginning of a golden age in antibiotic discovery with new antibiotics readily discovered from natural sources and refined into therapies that saved millions of lives. Towards the end of the last century, the rate of discovery slowed to a near standstill. The lack of discovery is compounded by the rapid emergence and spread of bacterial pathogens that exhibit resistance to multiple antibiotic therapies and threaten the sustainability of global healthcare systems. Acinetobacter baumannii is an opportunistic pathogen whose prevalence and impact has grown significantly over the last 20 years. It is recognised as a barometer of the antibiotic resistance crisis due to the diverse array of mechanisms by which it can become resistant.
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Published date: 19 October 2021
Additional Information:
© 2021. Springer Nature Switzerland AG.
Keywords:
Acinetobacter baumannii, Anti-Bacterial Agents/pharmacology, Bacteria, Drug Resistance, Multiple, Bacterial/genetics
Identifiers
Local EPrints ID: 506443
URI: http://eprints.soton.ac.uk/id/eprint/506443
ISSN: 0065-2598
PURE UUID: c3982ff0-53e3-41d3-98b2-edd237dc6e1e
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Date deposited: 07 Nov 2025 17:35
Last modified: 08 Nov 2025 03:19
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Contributors
Author:
Ronan R. McCarthy
Author:
Gerald J. Larrouy-Maumus
Author:
Mei Gei C. Meiqi Tan
Author:
David W. Wareham
Editor:
U. Kishore
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