Advances in liver and pancreas organoids: how far we have come and where we go next
Advances in liver and pancreas organoids: how far we have come and where we go next
Over the past decade, advances in organoid culturing methods have enabled the growth of three-dimensional cellular cultures in vitro with increasing fidelity with respect to the cellular composition, architecture and function of in vivo organs. The increased accessibility and ability to manipulate organoids as an in vitro system have led to a shift in the landscape of experimental biology. Whether derived from stem cells or tissue-resident cells, organoids are now routinely used in studies of development, homeostasis, regeneration and disease modelling, including viral infection and cancer. These applications of organoids are highly relevant for gastrointestinal tissues, including the liver and pancreas. In this Review, we explore the current and emerging advances in liver and pancreas organoid technologies for both discovery and clinical translation research and provide an outlook on the challenges ahead.
Sljukic, Aleksandra
71f91178-ea05-4ac5-907a-db5a2ee4299c
Jenkinson, Joshua Green
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Niksic, Armin
968c7875-bb31-4001-9785-dd356cddb98c
Prior, Nicole
27851f03-6041-4409-a15c-a2a164b883e0
Huch, Meritxell
defdc21f-6ca2-4a97-ab38-436adce9d37c
Sljukic, Aleksandra
71f91178-ea05-4ac5-907a-db5a2ee4299c
Jenkinson, Joshua Green
46cb150a-d748-4a66-b71e-75bf20720c50
Niksic, Armin
968c7875-bb31-4001-9785-dd356cddb98c
Prior, Nicole
27851f03-6041-4409-a15c-a2a164b883e0
Huch, Meritxell
defdc21f-6ca2-4a97-ab38-436adce9d37c
Sljukic, Aleksandra, Jenkinson, Joshua Green, Niksic, Armin, Prior, Nicole and Huch, Meritxell
(2025)
Advances in liver and pancreas organoids: how far we have come and where we go next.
Nature Reviews Gastroenterology & Hepatology.
(doi:10.1038/s41575-025-01116-1).
Abstract
Over the past decade, advances in organoid culturing methods have enabled the growth of three-dimensional cellular cultures in vitro with increasing fidelity with respect to the cellular composition, architecture and function of in vivo organs. The increased accessibility and ability to manipulate organoids as an in vitro system have led to a shift in the landscape of experimental biology. Whether derived from stem cells or tissue-resident cells, organoids are now routinely used in studies of development, homeostasis, regeneration and disease modelling, including viral infection and cancer. These applications of organoids are highly relevant for gastrointestinal tissues, including the liver and pancreas. In this Review, we explore the current and emerging advances in liver and pancreas organoid technologies for both discovery and clinical translation research and provide an outlook on the challenges ahead.
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Accepted/In Press date: 2025
e-pub ahead of print date: 10 October 2025
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Local EPrints ID: 506454
URI: http://eprints.soton.ac.uk/id/eprint/506454
ISSN: 1759-5045
PURE UUID: 49830577-25a3-4613-9b8a-1f19b3141614
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Date deposited: 07 Nov 2025 17:42
Last modified: 08 Nov 2025 03:07
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Author:
Aleksandra Sljukic
Author:
Joshua Green Jenkinson
Author:
Armin Niksic
Author:
Meritxell Huch
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