Role of endocrine and inflammatory alterations in comorbid somatic diseases of posttraumatic stress disorder
Role of endocrine and inflammatory alterations in comorbid somatic diseases of posttraumatic stress disorder
Since its first description in the Diagnostic and Statistical Manual for Mental Disorders, post-traumatic stress disorder (PTSD) has been characterized as a disorder of altered affective functioning which causes tremendous distress. In addition, it has been recognized that PTSD is not only accompanied by ''poor health'' but also by a number of specific and non-specific ''somatic'' pathologies, such as cardiovascular, autoimmune and physical complaints/chronic pain. It has been hypothesized that alterations of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic-adrenal-medullary (SAM) and the immune system may mediate or facilitate these somatic conditions. The aims of this review are to summarize studies that report altered somatic functioning in PTSD and to review how endocrine and immune function differentially affect PTSD-related somatic malfunction. It is hypothesized that alterations of HPA axis and SAM system permit disinhibition of inflammatory mechanisms, which in turn foster the development of somatic diseases as well as self-reported physical complaints.
273-288
Rohleder, N.
51f1e27e-a370-4d8b-af5b-de3620e3a794
Karl, A.
8732bdcc-928e-490f-a18b-164b35b9c6b4
December 2006
Rohleder, N.
51f1e27e-a370-4d8b-af5b-de3620e3a794
Karl, A.
8732bdcc-928e-490f-a18b-164b35b9c6b4
Rohleder, N. and Karl, A.
(2006)
Role of endocrine and inflammatory alterations in comorbid somatic diseases of posttraumatic stress disorder.
Minerva Endocrinologica, 31 (4), .
Abstract
Since its first description in the Diagnostic and Statistical Manual for Mental Disorders, post-traumatic stress disorder (PTSD) has been characterized as a disorder of altered affective functioning which causes tremendous distress. In addition, it has been recognized that PTSD is not only accompanied by ''poor health'' but also by a number of specific and non-specific ''somatic'' pathologies, such as cardiovascular, autoimmune and physical complaints/chronic pain. It has been hypothesized that alterations of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic-adrenal-medullary (SAM) and the immune system may mediate or facilitate these somatic conditions. The aims of this review are to summarize studies that report altered somatic functioning in PTSD and to review how endocrine and immune function differentially affect PTSD-related somatic malfunction. It is hypothesized that alterations of HPA axis and SAM system permit disinhibition of inflammatory mechanisms, which in turn foster the development of somatic diseases as well as self-reported physical complaints.
This record has no associated files available for download.
More information
Published date: December 2006
Identifiers
Local EPrints ID: 50662
URI: http://eprints.soton.ac.uk/id/eprint/50662
ISSN: 0391-1977
PURE UUID: 89768e67-8e3a-447d-96aa-aa7e092ee724
Catalogue record
Date deposited: 11 Mar 2008
Last modified: 27 Apr 2022 06:24
Export record
Contributors
Author:
N. Rohleder
Author:
A. Karl
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics