Takeuchi, Hikaru, Taki, Yasuyuki, Nouchi, Rui, Yokoyama, Ryoichi, Kotozaki, Yuka, Nakagawa, Seishu, Sekiguchi, Atsushi, Iizuka, Kunio, Yamamoto, Yuki, Hanawa, Sugiko, Araki, Tsuyoshi, Miyauchi, Carlos Makoto, Sakaki, Kohei, Nozawa, Takayuki, Ikeda, Shigeyuki, Yokota, Susumu, Daniele, Magistro, Sassa, Yuko and Kawashima, Ryuta (2020) Association of iron levels in hair with brain structures and functions in young adults. Journal of Trace Elements in Medicine and Biology, 58, [126436]. (doi:10.1016/j.jtemb.2019.126436).
Abstract
Background Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. Methods Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. Results Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. Conclusion These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
More information
Identifiers
Catalogue record
Export record
Altmetrics
Contributors
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.