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A Consensus statement on the management of vertebral fractures in CKD stages G4-G5D

A Consensus statement on the management of vertebral fractures in CKD stages G4-G5D
A Consensus statement on the management of vertebral fractures in CKD stages G4-G5D
Skeletal fragility has long been overlooked by the nephrology community, despite patients with chronic kidney disease (CKD) facing double the risk of hip fracture compared with the general population. Consequently, the term CKD-associated osteoporosis was recently coined to increase awareness. In this context, vertebral fractures are even less studied. Vertebral fractures predict increased fracture risk, and especially in advanced CKD show a strong association with aortic and iliac vascular calcifications, and cardiovascular events such as myocardial infarction. The scope of the present consensus paper is to comprehensively discuss the management of skeletal fragility in CKD patients, from diagnosis to treatment, with a particular focus on vertebral fractures in CKD G4-G5D.
1460-2385
Fusaro, Maria
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Harvey, Nicholas
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Napoli, Nicola
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Haarhaus, Mathias
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Ferraro, Pietro Manuel
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Bellasi, Antonio
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Moyses, Rosa
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Brandi, Maria L
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Fusaro, Maria
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Nickolas, Thomas
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Cossettini, Althea
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Ebeling, Peter R
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Napoli, Nicola
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Brandi, Maria L
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Fusaro, Maria, Chandran, Manju, Nickolas, Thomas, Ferrari, Serge, Cossettini, Althea, Ebeling, Peter R, Closkey, Eugene Mc, Harvey, Nicholas, Pierroz, Dominque D, Cannata-Andia, Jorge, Cheung, Angela, Guglielmi, Giuseppe, Glüer, Claus, Foldes, Joseph, W, Lems, Trombetti, Andrea, Mithal, Ambrish, Napoli, Nicola, Haarhaus, Mathias, Ferraro, Pietro Manuel, Ketteler, Markus, Bellasi, Antonio, Moyses, Rosa, Evenepoel, Pieter, Jørgensen, Hanne Skou, Reginster, Jean-Yves, Halbout, Philippe, Bover, Jordi, Gallieni, Maurizio, Salam, Syazrah, Eastell, Richard, Hansen, Ditte, Cavalier, E and Brandi, Maria L (2025) A Consensus statement on the management of vertebral fractures in CKD stages G4-G5D. Nephrology Dialysis and Transplantation. (doi:10.1093/ndt/gfaf256).

Record type: Article

Abstract

Skeletal fragility has long been overlooked by the nephrology community, despite patients with chronic kidney disease (CKD) facing double the risk of hip fracture compared with the general population. Consequently, the term CKD-associated osteoporosis was recently coined to increase awareness. In this context, vertebral fractures are even less studied. Vertebral fractures predict increased fracture risk, and especially in advanced CKD show a strong association with aortic and iliac vascular calcifications, and cardiovascular events such as myocardial infarction. The scope of the present consensus paper is to comprehensively discuss the management of skeletal fragility in CKD patients, from diagnosis to treatment, with a particular focus on vertebral fractures in CKD G4-G5D.

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gfaf256 - Version of Record
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Published date: 28 November 2025
Additional Information: © The Author(s) 2025. Published by Oxford University Press on behalf of the ERA.
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Identifiers

Local EPrints ID: 507272
URI: http://eprints.soton.ac.uk/id/eprint/507272
DOI: doi:10.1093/ndt/gfaf256
ISSN: 1460-2385
PURE UUID: ad141ad8-9ca0-4f4d-800f-268af17cfa31
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 02 Dec 2025 18:12
Last modified: 03 Dec 2025 02:39

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Contributors

Author: Maria Fusaro
Author: Manju Chandran
Author: Thomas Nickolas
Author: Serge Ferrari
Author: Althea Cossettini
Author: Peter R Ebeling
Author: Eugene Mc Closkey
Author: Nicholas Harvey ORCID iD
Author: Dominque D Pierroz
Author: Jorge Cannata-Andia
Author: Angela Cheung
Author: Giuseppe Guglielmi
Author: Claus Glüer
Author: Joseph Foldes
Author: Lems W
Author: Andrea Trombetti
Author: Ambrish Mithal
Author: Nicola Napoli
Author: Mathias Haarhaus
Author: Pietro Manuel Ferraro
Author: Markus Ketteler
Author: Antonio Bellasi
Author: Rosa Moyses
Author: Pieter Evenepoel
Author: Hanne Skou Jørgensen
Author: Jean-Yves Reginster
Author: Philippe Halbout
Author: Jordi Bover
Author: Maurizio Gallieni
Author: Syazrah Salam
Author: Richard Eastell
Author: Ditte Hansen
Author: E Cavalier
Author: Maria L Brandi

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