Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy
Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy
The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).
Bordetella pertussis, Immunoglobulin G, Multiplex, Preterm, Serology, Vaccine
Daniel, Olwenn
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Srikanth, Sashank
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Clarke, Paul
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Le Doare, Kirsty
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Heath, Paul T.
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Jones, Christine E.
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Scorrer, Tim
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Snape, Matthew
132c3c2d-eda6-4ee0-b853-356b08aa6488
Calvert, Anna
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12 July 2025
Daniel, Olwenn
05f1ece4-da5e-4d38-87bf-97bc63ec4b34
Srikanth, Sashank
77341665-97ae-4e39-b903-d560d708cb9a
Clarke, Paul
962f7c73-1c1e-4719-bfc4-9e5e8ac1fe9c
Le Doare, Kirsty
9424dc5c-4484-41d3-86dd-29cfaffb43f5
Heath, Paul T.
751321bd-5245-4f79-b57a-6d3b6de61b32
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Scorrer, Tim
f0c5dbf1-c32c-46df-90f6-c1bc6ac17e1b
Snape, Matthew
132c3c2d-eda6-4ee0-b853-356b08aa6488
Calvert, Anna
2a51489e-8ea4-4b6c-a439-ef1df57999bb
Daniel, Olwenn, Srikanth, Sashank, Clarke, Paul, Le Doare, Kirsty, Heath, Paul T., Jones, Christine E., Scorrer, Tim, Snape, Matthew and Calvert, Anna
(2025)
Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy.
Vaccine, 62, [127481].
(doi:10.1016/j.vaccine.2025.127481).
Abstract
The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).
Text
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Accepted/In Press date: 2 July 2025
e-pub ahead of print date: 12 July 2025
Published date: 12 July 2025
Keywords:
Bordetella pertussis, Immunoglobulin G, Multiplex, Preterm, Serology, Vaccine
Identifiers
Local EPrints ID: 507556
URI: http://eprints.soton.ac.uk/id/eprint/507556
ISSN: 0264-410X
PURE UUID: b4af5cfd-dc4c-4200-8473-aa548126d48e
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Date deposited: 12 Dec 2025 17:33
Last modified: 13 Dec 2025 02:49
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Contributors
Author:
Olwenn Daniel
Author:
Sashank Srikanth
Author:
Paul Clarke
Author:
Kirsty Le Doare
Author:
Paul T. Heath
Author:
Tim Scorrer
Author:
Matthew Snape
Author:
Anna Calvert
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