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Focussing on appetite decline to optimise management of undernutrition in later life - a geriatric medicine perspective

Focussing on appetite decline to optimise management of undernutrition in later life - a geriatric medicine perspective
Focussing on appetite decline to optimise management of undernutrition in later life - a geriatric medicine perspective
Undernutrition is common amongst older people and can lead to adverse health outcomes and increased dependence. This review focuses on an aspect of undernutrition that is often overlooked, namely loss of appetite, and will discuss the challenges in this under-researched field from the perspective of geriatric medicine. Appetite decline is common in later life and predicts undernutrition in older populations. As such, timely identification and intervention on poor appetite could delay onset or progression of undernutrition to optimise healthy ageing and maintain independence. In addition, management of undernutrition ultimately requires the individual to meet their nutritional requirements. However, unless attention is paid to mitigating appetite decline, strategies to improve intake are likely to be ineffective. Treatment for appetite decline is challenging due to the multiple and complex underlying mechanisms. Current evidence is limited to a few trials targeting older people including flavour enhancement and fortification or supplementation, lifestyle measures such as increasing physical activity and social interaction, and medications, all with mixed results. Progress on treatments for appetite decline has been hampered by a lack of distinction from undernutrition, but also perhaps the approach to it as a concept. Categorising appetite decline in ageing as a geriatric syndrome could aid progress in the unification of approaches to mechanistic research, assessment and management strategies, which are likely to be most effective when in multi-component form and underpinned by the principles of Comprehensive Geriatric Assessment (CGA).
0029-6651
Cox, Natalie J.
dfdfbc5f-41b8-4329-a4b5-87b6e93aa09e
Jones, Liam
1758fb40-58a5-4a34-a231-7ad56275c27a
Lim, Stephen E.R.
dd2bfbd7-7f74-4365-b77e-9989f6408ddc
Cox, Natalie J.
dfdfbc5f-41b8-4329-a4b5-87b6e93aa09e
Jones, Liam
1758fb40-58a5-4a34-a231-7ad56275c27a
Lim, Stephen E.R.
dd2bfbd7-7f74-4365-b77e-9989f6408ddc

Cox, Natalie J., Jones, Liam and Lim, Stephen E.R. (2025) Focussing on appetite decline to optimise management of undernutrition in later life - a geriatric medicine perspective. Proceedings of the Nutrition Society. (In Press)

Record type: Review

Abstract

Undernutrition is common amongst older people and can lead to adverse health outcomes and increased dependence. This review focuses on an aspect of undernutrition that is often overlooked, namely loss of appetite, and will discuss the challenges in this under-researched field from the perspective of geriatric medicine. Appetite decline is common in later life and predicts undernutrition in older populations. As such, timely identification and intervention on poor appetite could delay onset or progression of undernutrition to optimise healthy ageing and maintain independence. In addition, management of undernutrition ultimately requires the individual to meet their nutritional requirements. However, unless attention is paid to mitigating appetite decline, strategies to improve intake are likely to be ineffective. Treatment for appetite decline is challenging due to the multiple and complex underlying mechanisms. Current evidence is limited to a few trials targeting older people including flavour enhancement and fortification or supplementation, lifestyle measures such as increasing physical activity and social interaction, and medications, all with mixed results. Progress on treatments for appetite decline has been hampered by a lack of distinction from undernutrition, but also perhaps the approach to it as a concept. Categorising appetite decline in ageing as a geriatric syndrome could aid progress in the unification of approaches to mechanistic research, assessment and management strategies, which are likely to be most effective when in multi-component form and underpinned by the principles of Comprehensive Geriatric Assessment (CGA).

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Accepted/In Press date: 17 November 2025

Identifiers

Local EPrints ID: 507597
URI: http://eprints.soton.ac.uk/id/eprint/507597
ISSN: 0029-6651
PURE UUID: 5cf7d65c-5ecb-4e65-9ad9-17deb66e489f
ORCID for Natalie J. Cox: ORCID iD orcid.org/0000-0002-4297-1206
ORCID for Liam Jones: ORCID iD orcid.org/0000-0001-7323-5255
ORCID for Stephen E.R. Lim: ORCID iD orcid.org/0000-0003-2496-2362

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Date deposited: 15 Dec 2025 17:37
Last modified: 16 Dec 2025 03:09

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Contributors

Author: Natalie J. Cox ORCID iD
Author: Liam Jones ORCID iD

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