The impact of phytochemicals present in the diet on microbial signalling in the human gut
The impact of phytochemicals present in the diet on microbial signalling in the human gut
Diet has a significant impact on shaping the human gut microbiome; this could be partially due to the ability of certain phytochemicals found in the diet to interfere with native microbial signalling. Compounds isolated from foods such as garlic, coffee and grapefruit have all been shown to have a significant impact on the virulence potential of known pathogens such as Pseudomonas aeruginosa in vitro. This impact on pathogenicity is the result of the ability of phytochemicals isolated from these foods to inhibit of quorum sensing. These phytochemicals with quorum sensing inhibitory activity have the potential to be developed as next generation antimicrobials, which inhibit key virulence processes utilised by bacteria to establish infection while reducing the probability of selecting for resistance. These phytochemicals have the potential to be exploited as ingredients in nutraceuticals, functional food ingredients and pharmaceuticals that are capable of improving the efficacy of traditional antibiotic therapies.
684-691
Mccarthy, R.R.
0b2cf2e0-b0ff-4c92-aa04-92d91182d1f2
O'Gara, F.
f78c890a-1a3b-4436-bf7f-baa2e6df7f7b
April 2015
Mccarthy, R.R.
0b2cf2e0-b0ff-4c92-aa04-92d91182d1f2
O'Gara, F.
f78c890a-1a3b-4436-bf7f-baa2e6df7f7b
Mccarthy, R.R. and O'Gara, F.
(2015)
The impact of phytochemicals present in the diet on microbial signalling in the human gut.
Journal of Functional Foods, 14, .
(doi:10.1016/j.jff.2015.02.032).
Abstract
Diet has a significant impact on shaping the human gut microbiome; this could be partially due to the ability of certain phytochemicals found in the diet to interfere with native microbial signalling. Compounds isolated from foods such as garlic, coffee and grapefruit have all been shown to have a significant impact on the virulence potential of known pathogens such as Pseudomonas aeruginosa in vitro. This impact on pathogenicity is the result of the ability of phytochemicals isolated from these foods to inhibit of quorum sensing. These phytochemicals with quorum sensing inhibitory activity have the potential to be developed as next generation antimicrobials, which inhibit key virulence processes utilised by bacteria to establish infection while reducing the probability of selecting for resistance. These phytochemicals have the potential to be exploited as ingredients in nutraceuticals, functional food ingredients and pharmaceuticals that are capable of improving the efficacy of traditional antibiotic therapies.
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Accepted/In Press date: 18 February 2015
e-pub ahead of print date: 13 March 2015
Published date: April 2015
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Local EPrints ID: 507943
URI: http://eprints.soton.ac.uk/id/eprint/507943
ISSN: 1756-4646
PURE UUID: 3a733f0e-4351-445a-a59a-19fc48e7558b
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Date deposited: 08 Jan 2026 17:33
Last modified: 09 Jan 2026 03:10
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Author:
R.R. Mccarthy
Author:
F. O'Gara
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