Meningococcal disease associated with an acute post-streptococcal complement deficiency
Meningococcal disease associated with an acute post-streptococcal complement deficiency
Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin, or are secondary to consumption of complement by systemic lupus erythematosus (SLE) or membranoproliferative glomerulonephritis (MPGN). Whatever the cause, the complement deficiency is always chronic. Here we report a case of meningococcal disease (MCD) in a child with a transient complement deficiency (CD), caused by post-streptococcal glomerulonephritis (PSGN).
747-749
Daskas, Nikolaos
31c0cbcd-3a95-441c-9c38-c6359df8d327
Farmer, Katie
02eac698-5ef4-4b62-8a62-3601250385a2
Coward, Richard
4556d390-a7a9-4a8b-afe9-ad29d5bc4e05
Erlewyn-Lajeunesse, Michel
e1763b6d-165b-45c5-9108-5dc8722220b9
1 May 2007
Daskas, Nikolaos
31c0cbcd-3a95-441c-9c38-c6359df8d327
Farmer, Katie
02eac698-5ef4-4b62-8a62-3601250385a2
Coward, Richard
4556d390-a7a9-4a8b-afe9-ad29d5bc4e05
Erlewyn-Lajeunesse, Michel
e1763b6d-165b-45c5-9108-5dc8722220b9
Daskas, Nikolaos, Farmer, Katie, Coward, Richard and Erlewyn-Lajeunesse, Michel
(2007)
Meningococcal disease associated with an acute post-streptococcal complement deficiency.
Pediatric Nephrology, 22, .
(doi:10.1007/s00467-006-0394-x).
Abstract
Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin, or are secondary to consumption of complement by systemic lupus erythematosus (SLE) or membranoproliferative glomerulonephritis (MPGN). Whatever the cause, the complement deficiency is always chronic. Here we report a case of meningococcal disease (MCD) in a child with a transient complement deficiency (CD), caused by post-streptococcal glomerulonephritis (PSGN).
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Accepted/In Press date: 9 November 2006
Published date: 1 May 2007
Identifiers
Local EPrints ID: 508157
URI: http://eprints.soton.ac.uk/id/eprint/508157
ISSN: 0931-041X
PURE UUID: fd166433-d72c-4595-b6f2-ed8cf9687746
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Date deposited: 14 Jan 2026 17:31
Last modified: 15 Jan 2026 02:55
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Author:
Nikolaos Daskas
Author:
Katie Farmer
Author:
Richard Coward
Author:
Michel Erlewyn-Lajeunesse
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