Hyperimmunoglobulin-E syndrome with recurrent infection: a review of current opinion and treatment
Hyperimmunoglobulin-E syndrome with recurrent infection: a review of current opinion and treatment
Hyperimmunoglobulin E (hyper-IgE) syndrome with recurrent infection is a rare idiopathic primary immunodeficiency. It consists of a severe dermatitis with recurrent abscess formation, respiratory tract infections and very high titres of serum immunoglobulin E (IgE). Hyper-IgE syndrome is also associated with skeletal abnormalities. Variability of presentation makes it easy to confuse the diagnosis with that of severe atopy or other rare immunodeficiencies. The aim of this article is to review the literature in order to consider the clinical findings, etiology and treatment of this syndrome.
133-141
Erlewyn-Lajeunesse, Michel D.S.
e1763b6d-165b-45c5-9108-5dc8722220b9
9 October 2008
Erlewyn-Lajeunesse, Michel D.S.
e1763b6d-165b-45c5-9108-5dc8722220b9
Erlewyn-Lajeunesse, Michel D.S.
(2008)
Hyperimmunoglobulin-E syndrome with recurrent infection: a review of current opinion and treatment.
Pediatric Allergy and Immunology, 11 (3), .
(doi:10.1034/j.1399-3038.2000.00091.x).
Abstract
Hyperimmunoglobulin E (hyper-IgE) syndrome with recurrent infection is a rare idiopathic primary immunodeficiency. It consists of a severe dermatitis with recurrent abscess formation, respiratory tract infections and very high titres of serum immunoglobulin E (IgE). Hyper-IgE syndrome is also associated with skeletal abnormalities. Variability of presentation makes it easy to confuse the diagnosis with that of severe atopy or other rare immunodeficiencies. The aim of this article is to review the literature in order to consider the clinical findings, etiology and treatment of this syndrome.
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Accepted/In Press date: 10 May 2000
Published date: 9 October 2008
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Local EPrints ID: 508159
URI: http://eprints.soton.ac.uk/id/eprint/508159
ISSN: 0905-6157
PURE UUID: 8238e14c-7ee5-41c9-a4fd-19e96b51ea8a
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Date deposited: 14 Jan 2026 17:31
Last modified: 15 Jan 2026 02:55
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Author:
Michel D.S. Erlewyn-Lajeunesse
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