Randomised controlled trial of combined paracetamol and ibuprofen for fever
Randomised controlled trial of combined paracetamol and ibuprofen for fever
Every day parents and healthcare professionals treat febrile children using ibuprofen and paracetamol. The practice of giving both medicines simultaneously is widespread,1 but unsupported by evidence. Their use has been driven in part by a perceived need to prevent febrile convulsion, although evidence that antipyretics prevent such convulsions is also lacking.2 We assessed the short term effectiveness of a combined dose of paracetamol and ibuprofen in reducing childhood fever.
414-416
Erlewyn-Lajeunesse, M D S
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Coppens, K.
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Hunt, L.P.
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Chinnick, P.J.
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Davies, P.
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Higginson, I.M.
ecc01a1f-8c77-4329-a686-3aca522168ad
Benger, J.R.
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Erlewyn-Lajeunesse, M D S
e1763b6d-165b-45c5-9108-5dc8722220b9
Coppens, K.
55ab1433-032b-4309-9171-d41ad4ac3127
Hunt, L.P.
f70289be-162c-4a6a-9134-6cdd552c8c43
Chinnick, P.J.
58f2a54b-6de9-47fb-9600-ae1a8902912a
Davies, P.
70d70196-8d38-4cbc-8ca0-3e37c581cf41
Higginson, I.M.
ecc01a1f-8c77-4329-a686-3aca522168ad
Benger, J.R.
7c17ea88-b073-489e-af50-0220c2ccf53f
Erlewyn-Lajeunesse, M D S, Coppens, K., Hunt, L.P., Chinnick, P.J., Davies, P., Higginson, I.M. and Benger, J.R.
(2006)
Randomised controlled trial of combined paracetamol and ibuprofen for fever.
Archives of Disease in Childhood, .
(doi:10.1136/adc.2005.087874).
Abstract
Every day parents and healthcare professionals treat febrile children using ibuprofen and paracetamol. The practice of giving both medicines simultaneously is widespread,1 but unsupported by evidence. Their use has been driven in part by a perceived need to prevent febrile convulsion, although evidence that antipyretics prevent such convulsions is also lacking.2 We assessed the short term effectiveness of a combined dose of paracetamol and ibuprofen in reducing childhood fever.
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Accepted/In Press date: 1 February 2006
e-pub ahead of print date: 7 February 2006
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Local EPrints ID: 508206
URI: http://eprints.soton.ac.uk/id/eprint/508206
ISSN: 0003-9888
PURE UUID: aba34955-7679-473c-b3b9-de46ef556166
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Date deposited: 14 Jan 2026 17:53
Last modified: 15 Jan 2026 02:55
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Contributors
Author:
M D S Erlewyn-Lajeunesse
Author:
K. Coppens
Author:
L.P. Hunt
Author:
P.J. Chinnick
Author:
P. Davies
Author:
I.M. Higginson
Author:
J.R. Benger
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