Unscrambling egg allergy: the diagnostic value of specific IgE concentrations and skin prick tests for Ovomucoid and egg white in the management of children with hen’s egg allergy
Unscrambling egg allergy: the diagnostic value of specific IgE concentrations and skin prick tests for Ovomucoid and egg white in the management of children with hen’s egg allergy
Resolution of egg allergy occurs in the majority of egg allergic children. Positive specific IgE antibodies to ovomucoid (OVM) have been suggested to be of greater predictive value for persistent egg allergy than specific IgE to egg white. The performance of OVM-specific IgE antibody levels in a cohort of children referred for a routine egg challenge was compared with egg white specific IgE levels in predicting a positive egg challenge. 24/47 subjects had persistent egg allergy. Receiver operating characteristic analysis showed that OVM-specific IgE testing was the most useful test for the diagnosis of persistent egg allergy. The optimal decision points for the prediction of persistent egg allergy were >0.35 kUA/L for specific IgE levels to both EW and OVM, and ≥3 mm for SPT. Children with specific IgE levels suggestive of persistent egg allergy need not be subject to an egg provocation challenge, reducing both costs and risks to the child.
Marriage, D. E.
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Erlewyn-Lajeunesse, M.
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Unsworth, D. J.
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Henderson, A. J.
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Marriage, D. E.
ef186bce-d982-4c22-9414-a63aef95e51a
Erlewyn-Lajeunesse, M.
e1763b6d-165b-45c5-9108-5dc8722220b9
Unsworth, D. J.
d713d734-76cc-4642-9c32-47886bd9becd
Henderson, A. J.
7721d939-f56e-4f30-9aaf-e137ca4257bc
Marriage, D. E., Erlewyn-Lajeunesse, M., Unsworth, D. J. and Henderson, A. J.
(2012)
Unscrambling egg allergy: the diagnostic value of specific IgE concentrations and skin prick tests for Ovomucoid and egg white in the management of children with hen’s egg allergy.
ISRN Allergy, 2012 (1).
(doi:10.5402/2012/627545).
Abstract
Resolution of egg allergy occurs in the majority of egg allergic children. Positive specific IgE antibodies to ovomucoid (OVM) have been suggested to be of greater predictive value for persistent egg allergy than specific IgE to egg white. The performance of OVM-specific IgE antibody levels in a cohort of children referred for a routine egg challenge was compared with egg white specific IgE levels in predicting a positive egg challenge. 24/47 subjects had persistent egg allergy. Receiver operating characteristic analysis showed that OVM-specific IgE testing was the most useful test for the diagnosis of persistent egg allergy. The optimal decision points for the prediction of persistent egg allergy were >0.35 kUA/L for specific IgE levels to both EW and OVM, and ≥3 mm for SPT. Children with specific IgE levels suggestive of persistent egg allergy need not be subject to an egg provocation challenge, reducing both costs and risks to the child.
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International Scholarly Research Notices - 2012 - Marriage - Unscrambling Egg Allergy The Diagnostic Value of Specific IgE
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e-pub ahead of print date: 9 February 2012
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Local EPrints ID: 508220
URI: http://eprints.soton.ac.uk/id/eprint/508220
ISSN: 2090-553X
PURE UUID: eec38dd2-b45b-4f43-845f-09cea9ce1e75
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Date deposited: 14 Jan 2026 18:04
Last modified: 15 Jan 2026 02:55
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Author:
D. E. Marriage
Author:
M. Erlewyn-Lajeunesse
Author:
D. J. Unsworth
Author:
A. J. Henderson
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