Ronan, McCarthy (Inventors) (2024) Compositions for preventing and treating infection. GB2627152.
Abstract
Composition including cyclamate in an amount sufficient to inhibit bacterial growth and/or virulence for use in a method of treating and/or preventing infection of a wound. The infection may be bacterial and caused by Pseudomonas aeruginosa, Acinetobacter baumannii, Enterococcus faecalis, Klebsiella pneumoniae, Stenotrophomonas maltophilia or Enterobacter. The composition may inhibit biofilm formation and/or bacterial motility. The cyclamate may be sodium cyclamate. The composition may be formulated for application to a patients skin (e.g. for application to a wound; or as a liquid, cream ointment, gel or hydrogel), for inhalation (e.g. in an aerosolised or dry powder form) or for intravenous administration. The composition may be included in a wound dressing for topical application.
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