Ronan, McCarthy (Inventors) (2023) Compositions for preventing and treating infection. GB2617603.
Abstract
Composition including an artificial sweetener (e.g. ace-K, saccharin, sucralose, cyclamate, sugar alcohol (e.g. xylitol, mannitol, sorbitol, erythritol, maltitol, lactitol)) or a derivative thereof in an amount sufficient to inhibit bacterial growth and/or virulence for use in a method of treating and/or preventing infection (e.g. infection caused by Pseudomonas aeruginosa, Acinetobacter baumannii, Enterococcus faecalis, Klebsiella pneumoniae, Stenotrophomonas maltophilia or an Enterobacter species. Such compositions may inhibit biofilm formation and/or bacterial motility. Further claimed is a composition including acesulfame potassium, cyclamate, saccharin or a derivative thereof, for use in enhancing the activity of an antibiotic, preferably wherein the acesulfame-K, saccharin or cyclohexylsulfamate are present below a minimum inhibitory concentration, most preferably present at less than 1 % (w/v), such a composition may be co-administered with a beta-lactam, carbapenem, aminoglycoside, polymyxin. The compositions may be applied topically, orally, intravenously or via inhalation.
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