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Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans

Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans
Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans
Nociception, a phenomenon crucial for animal survival, deploys evolutionarily conserved molecular mechanisms. Among invertebrate species, cephalopods are of particular interest as they possess a well-developed brain speculated to be able to encode pain-like states. This has led to their inclusion in the Directive 2010/63 EU for welfare protection.
2046-6390
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
O'connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Dillon, James
f406e30a-3ad4-4a53-80db-6694bab5e3ed
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
O'connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Dillon, James
f406e30a-3ad4-4a53-80db-6694bab5e3ed

Holden-Dye, Lindy, O'connor, Vincent and Dillon, James (2025) Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans. Biology Open. (doi:10.1242/bio.062268).

Record type: Article

Abstract

Nociception, a phenomenon crucial for animal survival, deploys evolutionarily conserved molecular mechanisms. Among invertebrate species, cephalopods are of particular interest as they possess a well-developed brain speculated to be able to encode pain-like states. This has led to their inclusion in the Directive 2010/63 EU for welfare protection.

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e-pub ahead of print date: 23 December 2025
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Local EPrints ID: 508376
URI: http://eprints.soton.ac.uk/id/eprint/508376
DOI: doi:10.1242/bio.062268
ISSN: 2046-6390
PURE UUID: 29b194b5-ac65-4f67-a8a5-6f63b166a549
ORCID for Lindy Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217
ORCID for Vincent O'connor: ORCID iD orcid.org/0000-0003-3185-5709
ORCID for James Dillon: ORCID iD orcid.org/0000-0003-3244-7483

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Date deposited: 20 Jan 2026 17:44
Last modified: 21 Jan 2026 02:38

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Contributors

Author: Lindy Holden-Dye ORCID iD
Author: Vincent O'connor ORCID iD
Author: James Dillon ORCID iD

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