Optimizing a C. elegans whole organism screen biased for chemicals that target the nematode clade specific receptor EAT-2
Optimizing a C. elegans whole organism screen biased for chemicals that target the nematode clade specific receptor EAT-2
Pesticides are important resources in the control of pests and pathogens of plants and animals. Unfortunately, there are concerns around their broad impacts on non-target organisms and the environment. In this study we optimize a platform biased for the nicotinic acetylcholine receptor EAT-2, a physiological regulator of feeding in C. elegans. We show that by screening for chemicals that inhibit C. elegans pharyngeal pumping in lev-1(x427), we can identify lead compounds that modulate EAT-2 function. This provides a motivation for further studies to investigate the role of EAT-2 in parasitic nematodes and their potential as a target for novel nematicides.
10.17912
Nvenankeng, Henry Atemnkeng
e944da59-6e1b-444f-aa4b-f15b552f4d34
Goodchild, Jim
77aa73e3-9747-4b52-b681-ff3dbd4e1996
Harlow, Philippa
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O'connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Nvenankeng, Henry Atemnkeng
e944da59-6e1b-444f-aa4b-f15b552f4d34
Goodchild, Jim
77aa73e3-9747-4b52-b681-ff3dbd4e1996
Harlow, Philippa
2a7bc759-df33-4baf-bb5d-020d4aece422
O'connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Nvenankeng, Henry Atemnkeng, Goodchild, Jim, Harlow, Philippa, O'connor, Vincent and Holden-Dye, Lindy
(2025)
Optimizing a C. elegans whole organism screen biased for chemicals that target the nematode clade specific receptor EAT-2.
Micropublication Biology.
(doi:10.17912).
Abstract
Pesticides are important resources in the control of pests and pathogens of plants and animals. Unfortunately, there are concerns around their broad impacts on non-target organisms and the environment. In this study we optimize a platform biased for the nicotinic acetylcholine receptor EAT-2, a physiological regulator of feeding in C. elegans. We show that by screening for chemicals that inhibit C. elegans pharyngeal pumping in lev-1(x427), we can identify lead compounds that modulate EAT-2 function. This provides a motivation for further studies to investigate the role of EAT-2 in parasitic nematodes and their potential as a target for novel nematicides.
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micropub-biology-001814
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e-pub ahead of print date: 8 October 2025
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Local EPrints ID: 508457
URI: http://eprints.soton.ac.uk/id/eprint/508457
ISSN: 2578-9430
PURE UUID: 40b1bb2f-f4d0-4ca5-b5d3-63a36ddff015
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Date deposited: 22 Jan 2026 17:41
Last modified: 23 Jan 2026 02:36
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Author:
Henry Atemnkeng Nvenankeng
Author:
Jim Goodchild
Author:
Philippa Harlow
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