Therapeutic targeting of tumour-associated macrophage receptors.
Therapeutic targeting of tumour-associated macrophage receptors.
Tumour-associated macrophages (TAM) are present in the majority of tumours, where they comprise one of the most abundant cell types, influencing tumour progression, metastasis, therapy resistance, and relapse. Hence, there is a great interest in targeting TAMs to improve and complement anti-cancer treatments. However, further studies are needed to validate the potential of exploiting TAM cell surface markers for cancer immunotherapy. Here, we review the function of TAMs, their involvement in tumorigenesis, metastasis, and therapy resistance. Furthermore, we summarize the current landscape of key TAM cell surface receptors that are being investigated as potential targets for cancer immunotherapy, highlighting the promise and challenges associated with these approaches.
immunotherapy, monoclonal antibodies, tumour microenvironment, tumour-associated macrophages
Gomes Alves Martins, Rosa
eb63dd20-ce30-4fd9-9872-0e93839397c7
Tekin, Mehmet Masum
66961a4e-5e76-4d3a-b61c-3f8b1f0460dc
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
11 March 2025
Gomes Alves Martins, Rosa
eb63dd20-ce30-4fd9-9872-0e93839397c7
Tekin, Mehmet Masum
66961a4e-5e76-4d3a-b61c-3f8b1f0460dc
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Gomes Alves Martins, Rosa, Tekin, Mehmet Masum, Cragg, Mark and Roghanian, Ali
(2025)
Therapeutic targeting of tumour-associated macrophage receptors.
Immunotherapy Advances, 5 (1).
Abstract
Tumour-associated macrophages (TAM) are present in the majority of tumours, where they comprise one of the most abundant cell types, influencing tumour progression, metastasis, therapy resistance, and relapse. Hence, there is a great interest in targeting TAMs to improve and complement anti-cancer treatments. However, further studies are needed to validate the potential of exploiting TAM cell surface markers for cancer immunotherapy. Here, we review the function of TAMs, their involvement in tumorigenesis, metastasis, and therapy resistance. Furthermore, we summarize the current landscape of key TAM cell surface receptors that are being investigated as potential targets for cancer immunotherapy, highlighting the promise and challenges associated with these approaches.
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Accepted/In Press date: 5 March 2025
Published date: 11 March 2025
Keywords:
immunotherapy, monoclonal antibodies, tumour microenvironment, tumour-associated macrophages
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Local EPrints ID: 508482
URI: http://eprints.soton.ac.uk/id/eprint/508482
PURE UUID: 167bd0f8-a757-4620-8066-625452a011f3
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Date deposited: 23 Jan 2026 17:35
Last modified: 29 Jan 2026 05:21
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Contributors
Author:
Rosa Gomes Alves Martins
Author:
Mehmet Masum Tekin
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