Estcourt, Claudia S., Mapp, Fiona and Owusu, Melvina Woode , (2024) Improving sexual health through partner notification: the LUSTRUM mixed-methods research Programme including RCT of accelerated partner therapy. Programme Grants for Applied Research, 12 (2). (doi:10.3310/TRQW3886).
Abstract
Background: Sexually transmitted infections disproportionately affect young people and men who have sex with men. Chlamydia is Britain’s most common sexually transmitted infection. Partner notification is a key intervention to reduce transmission of sexually transmitted infections and human immunodeficiency virus but is hard to implement. Accelerated partner therapy is a promising new approach. Objectives: 1. determine the effectiveness, costs and acceptability of accelerated partner therapy for chlamydia in heterosexual people 2. model the cost effectiveness of accelerated partner therapy and impact on chlamydia transmission 3. develop and cost partner notification interventions for men who have sex with men. Design: Mixed-methods study to develop a new sex partner classification and optimise accelerated partner therapy; cluster crossover randomised controlled trial of accelerated partner therapy, with process and cost-consequence evaluation; dynamic modelling and health economic evaluation; systematic review of economic studies of partner notification for sexually transmitted infections in men who have sex with men; qualitative research to co-design a novel partner notification intervention for men who have sex with men with bacterial sexually transmitted infections. Settings: Sexual health clinics and community services in England and Scotland. Participants: Women and men, including men who have sex with men and people with mild learning disabilities. Interventions: Accelerated partner therapy offered as an additional partner notification method. Main outcome measures: Proportion of index patients with positive repeat chlamydia test (primary outcome); proportion of sex partners treated; costs per major outcome averted and quality-adjusted life-year; predicted chlamydia prevalence; experiences of accelerated partner therapy. Data sources: Randomised controlled trial: partnership type, resource use, outcomes, qualitative data: economic analysis, modelling and systematic review: resource use and unit costs from the randomised controlled trial, secondary sources. Results: The sex partner classification defined five types. Accelerated partner therapy modifications included simplified self-sampling packs and creation of training films. We created a clinical management and partner notification data collection system.
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