Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF-S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.
699-703
Chatchatee, Pantipa
29827c25-7c20-4766-b25d-dd4901c4cf12
Nowak-Wegrzyn, Anna
661bfdbf-32de-4421-9c1b-277c7b62861b
Lange, Lars
a73d0afb-9ccb-4130-bcb7-eb036446cf68
Erlewyn-Lajeunesse, Michel
e1763b6d-165b-45c5-9108-5dc8722220b9
19 March 2024
Chatchatee, Pantipa
29827c25-7c20-4766-b25d-dd4901c4cf12
Nowak-Wegrzyn, Anna
661bfdbf-32de-4421-9c1b-277c7b62861b
Lange, Lars
a73d0afb-9ccb-4130-bcb7-eb036446cf68
Erlewyn-Lajeunesse, Michel
e1763b6d-165b-45c5-9108-5dc8722220b9
Chatchatee, Pantipa, Nowak-Wegrzyn, Anna and Lange, Lars
,
et al. and PRESTO study team
(2024)
Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study).
Journal of Pediatric Gastroenterology and Nutrition, 78 (3), .
(doi:10.1002/jpn3.12104).
Abstract
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF-S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.
Text
J pediatr gastroenterol nutr - 2024 - Chatchatee - Tolerance development in cow s milk‐allergic children receiving amino
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Accepted/In Press date: 27 November 2023
e-pub ahead of print date: 14 January 2024
Published date: 19 March 2024
Identifiers
Local EPrints ID: 508707
URI: http://eprints.soton.ac.uk/id/eprint/508707
ISSN: 0277-2116
PURE UUID: bfcdab90-94d0-453e-b4c8-94df761a0a02
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Date deposited: 30 Jan 2026 17:48
Last modified: 31 Jan 2026 05:52
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Contributors
Author:
Pantipa Chatchatee
Author:
Anna Nowak-Wegrzyn
Author:
Lars Lange
Author:
Michel Erlewyn-Lajeunesse
Corporate Author: et al.
Corporate Author: PRESTO study team
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