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Shape-shifting microglia respond to neuronal hyperexcitability

Shape-shifting microglia respond to neuronal hyperexcitability
Shape-shifting microglia respond to neuronal hyperexcitability

The initial responses of microglia to neuronal stress or altered network activity are poorly characterized. Xie and colleagues show that during TDP-43-related neurodegeneration, microglia detect early neuronal hyperactivity and transition into a distinct rod-shaped state. This study uncovers a microglial state that precedes overt neuronal loss, shedding new light on the earliest stages of neurodegeneration.

Animals, DNA-Binding Proteins/metabolism, Humans, Mice, Microglia/physiology, Neurodegenerative Diseases/pathology, Neurons/physiology
1097-4180
2927-2930
Musi, Clara Alice
b6eafd83-3dc9-4922-b3e3-b00b2936e935
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Musi, Clara Alice
b6eafd83-3dc9-4922-b3e3-b00b2936e935
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5

Musi, Clara Alice and Gomez-Nicola, Diego (2025) Shape-shifting microglia respond to neuronal hyperexcitability. Immunity, 58 (12), 2927-2930. (doi:10.1016/j.immuni.2025.11.002).

Record type: Letter

Abstract

The initial responses of microglia to neuronal stress or altered network activity are poorly characterized. Xie and colleagues show that during TDP-43-related neurodegeneration, microglia detect early neuronal hyperactivity and transition into a distinct rod-shaped state. This study uncovers a microglial state that precedes overt neuronal loss, shedding new light on the earliest stages of neurodegeneration.

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More information

e-pub ahead of print date: 9 December 2025
Keywords: Animals, DNA-Binding Proteins/metabolism, Humans, Mice, Microglia/physiology, Neurodegenerative Diseases/pathology, Neurons/physiology
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Identifiers

Local EPrints ID: 508829
URI: http://eprints.soton.ac.uk/id/eprint/508829
DOI: doi:10.1016/j.immuni.2025.11.002
ISSN: 1097-4180
PURE UUID: f9d3e7f2-11db-42b2-b73c-f59f706d65e5
ORCID for Clara Alice Musi: ORCID iD orcid.org/0000-0002-5098-2052
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 04 Feb 2026 17:41
Last modified: 05 Feb 2026 03:10

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Contributors

Author: Clara Alice Musi ORCID iD
Author: Diego Gomez-Nicola ORCID iD

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