READ ME File For 'Supplementary data for article "Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections" '

Dataset DOI: 10.5258/SOTON/D3857

Date that the file was created: 11 February, 2026

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GENERAL INFORMATION
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ReadMe Author: Dr Negusse Tadesse Kitaba, University of Southampton [ORCID ID: https://orcid.org/0000-0001-7518-9096]

Date of data collection: 15-May-2020 to 04-Jan-2022 

Information about geographic location of data collection: Drakenstein Child Health Study (DCHS) Cape Town University, South Africa


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SHARING/ACCESS INFORMATION
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Licenses/restrictions placed on the data, or limitations of reuse: CC-BY

This dataset supports the publication:
AUTHORS: Negusse Tadesse Kitaba, Lesley Workman, Cheryl Cohen, Diana Baralle, Ellen Kong, Maresa Botha, Marina Johnson8, David Goldblatt, Mark P Nicol, John W Holloway and Heather J Zar
TITLE: Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections 
JOURNAL: BMC Infectious Diseases
PAPER DOI IF KNOWN: https://doi.org/10.1101/2025.11.07.687132

Links to other publicly accessible locations of the data: DOI: 10.1101/2025.11.07.687132

Links/relationships to ancillary or related data sets: DOI: 10.1101/2025.11.07.687132


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DATA & FILE OVERVIEW
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This supplemenatry_materials.zip dataset contains:

Supplementary  Table S1 Respiratory infection TWAS.xlsx
Supplementary  Table S2 TWAS enrichment.xlsx
Supplementary  Table S3 WGCNA module genes and eigengene.xlsx
Supplementary  Table S4 Network degree distribution.xlsx
Supplementary  Table S5 Enrichment for modules.xlsx
Supplementary  Table S6 Cell type proportions.xlsx
Supplementary  Table S7 severity predictors.xlsx
Supplementary  Table S8 Drug target look-up.xlsx
Supplementary  Table S9 target prioritization.xlsx
Supplementary Fig 1 Module dendrogram.png
Supplementary Fig 2 Distribution of genes per module.png
Supplementary Fig 3  Venn diagram shared modules.png
Supplementary Fig 4 REVIGO biological process .pdf
Supplementary Fig 5 Blood compostion.pdf
Supplementary Fig 6 Shared cell type.png
Supplementary Fig 7 Shared severity predictors for LRTI.png




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METHODOLOGICAL INFORMATION
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All the methodology was described in methods part of the article and available as pre-print: DOI: 10.1101/2025.11.07.687132