Couto Alves, Alex (2025) Bioinformatics pipeline and Data files used or generated in the ADPr-Seq methodology paper. University of Southampton doi:10.6084/m9.figshare.29092511 [Dataset]
Abstract
ADPr-Seq is the first high-throughput, genome-wide methodology for mapping a newly characterized DNA modification known as ADP-ribosylation. We introduce a novel robust and unbiased experimental protocol, coupled with a sensitive and accurate bionformatics methodology for quantifying ADP-ribosylation and performing differential binding analysis. Our approach is adaptable to other labile DNA modifications that are incompatible with conventional highenergy DNA fragmentation techniques. The resulting methodology is excetionally reliable, reproducible, sensitivity and unbiased, making it also suitable for experimetns and conditions with low quantities of DNA is produced.
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