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Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

1061-4036
902-906
Bønnelykke, Klaus
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Matheson, Melanie C.
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Dharmage, Shyamali C.
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James, Alan
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Waldenberger, Melanie
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Fairfax, Benjamin P.
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et al.
Bønnelykke, Klaus
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Matheson, Melanie C.
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Pers, Tune H.
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Granell, Raquel
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Strachan, David P.
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Alves, Alexessander Couto
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Linneberg, Allan
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Curtin, John A.
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Standl, Marie
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Kerkhof, Marjan
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Jonsdottir, Ingileif
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Bukvic, Blazenka K.
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Kaakinen, Marika
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Walters, Eugene H.
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Tiesler, Carla M.T.
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Duffy, David L.
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Jones, Graham
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Ring, Susan M.
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McArdle, Wendy L.
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Price, Loren
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Robertson, Colin F.
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Pekkanen, Juha
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Tang, Clara S.
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Thiering, Elisabeth
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Montgomery, Grant W.
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Hartikainen, Anna Liisa
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Dharmage, Shyamali C.
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Husemoen, Lise L.
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Herder, Christian
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Kemp, John P.
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Elliot, Paul
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James, Alan
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Waldenberger, Melanie
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Abramson, Michael J.
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Fairfax, Benjamin P.
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Knight, C. Julian
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Gupta, Ramneek
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Thompson, Philip J.
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Ferreira, Manuel A.
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Bønnelykke, Klaus, Matheson, Melanie C. and Pers, Tune H. , et al. (2013) Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45 (8), 902-906. (doi:10.1038/ng.2694).

Record type: Article

Abstract

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

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More information

Accepted/In Press date: 10 June 2013
e-pub ahead of print date: 30 June 2013
Published date: August 2013

Identifiers

Local EPrints ID: 509232
URI: http://eprints.soton.ac.uk/id/eprint/509232
DOI: doi:10.1038/ng.2694
ISSN: 1061-4036
PURE UUID: 2d137fe0-df6b-4160-8364-153f1eb7c8f4
ORCID for Alexessander Couto Alves: ORCID iD orcid.org/0000-0001-8519-7356

Catalogue record

Date deposited: 13 Feb 2026 17:49
Last modified: 14 Feb 2026 03:15

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Contributors

Author: Klaus Bønnelykke
Author: Melanie C. Matheson
Author: Tune H. Pers
Author: Raquel Granell
Author: David P. Strachan
Author: Alexessander Couto Alves ORCID iD
Author: Allan Linneberg
Author: John A. Curtin
Author: Nicole M. Warrington
Author: Marie Standl
Author: Marjan Kerkhof
Author: Ingileif Jonsdottir
Author: Blazenka K. Bukvic
Author: Marika Kaakinen
Author: Patrick Sleimann
Author: Gudmar Thorleifsson
Author: Unnur Thorsteinsdottir
Author: Katharina Schramm
Author: Svetlana Baltic
Author: Eskil Kreiner Møller
Author: Angela Simpson
Author: Beate St Pourcain
Author: Lachlan Coin
Author: Jennie Hui
Author: Eugene H. Walters
Author: Carla M.T. Tiesler
Author: David L. Duffy
Author: Graham Jones
Author: Susan M. Ring
Author: Wendy L. McArdle
Author: Loren Price
Author: Colin F. Robertson
Author: Juha Pekkanen
Author: Clara S. Tang
Author: Elisabeth Thiering
Author: Grant W. Montgomery
Author: Anna Liisa Hartikainen
Author: Shyamali C. Dharmage
Author: Lise L. Husemoen
Author: Christian Herder
Author: John P. Kemp
Author: Paul Elliot
Author: Alan James
Author: Melanie Waldenberger
Author: Michael J. Abramson
Author: Benjamin P. Fairfax
Author: C. Julian Knight
Author: Ramneek Gupta
Author: Philip J. Thompson
Author: Manuel A. Ferreira
Corporate Author: et al.

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