Mccarthy, Ronan (Inventors) (2025) Compositions for preventing and treating infection. GB2635253.
Abstract
Composition including ace-K, cyclamate or saccharin, or a chemically related derivative of any of these, for use in increasing the susceptibility of bacteria to an antibiotic. Composition may render an antibiotic resistance bacterium sensitive to the antibiotic. The composition may comprise an anti-biotic (e.g. beta-lactam, carbapenem, aminoglycoside, polymyxin). Composition may be formulated for application to a patients skin (e.g. as a liquid, cream, ointment, gel or hydrogel) and may be incorporated into a wound dressing. The composition may be suitable for inhalation (e.g. aerosolised or dry powder form). The composition may be formulated for intraveneous administration or for oral administration. The acesulfame-potassium, sodium cyclohexylsulfamate, sarrcharin may be present at less than 15 %w/v, such as below 1 %w/v and, preferably, are below their minimum inhibitory concentration. The bacterial species may be P. aeruginosa or A. baumannii. Also claimed is the composition for use in disrupting the membrane of the bacteria.
This record has no associated files available for download.
More information
Identifiers
Catalogue record
Export record
Contributors
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.