A non-toxic binuclear vanadium(IV) complex as insulin adjuvant improves the glycemic control in streptozotocin-induced diabetic rats
A non-toxic binuclear vanadium(IV) complex as insulin adjuvant improves the glycemic control in streptozotocin-induced diabetic rats
Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3NH)2[{VO(OH}2)(ox)2(µ–ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days. Vox2 at 100 mg/kg in association with insulin caused a 3.4 times decrease in blood glucose in STZ rats (424 mg/dL), reaching concentrations similar to those in the normoglycemic animals (126 mg/dL). Compared to insulin alone, the association with Vox2 caused an additional decrease in blood glucose of 39% and 65% at 30 and 100 mg/kg, respectively, and an increased pancreatic GSH levels 2.5 times. Vox2 alone did not cause gastrointestinal discomfort, diarrhea, and hepatic or renal toxicity and was not associated with changes in blood glucose level, lipid profile, or kidney or liver function. Our results highlight the potential of Vox2 in association with insulin in treating diabetes.
adjunctive to insulin therapies, oxidovanadium(IV), STZ-induced diabetic rats, treatment efficacy, vanadium
Lopes, Mateus S.
56c57601-183c-42c9-8c71-d619cffa2ebe
Baptistella, Gabriel B.
fed93f5f-fddd-4b55-ae90-6da552a507ee
Nunes, Giovana G.
eb346d2b-5f20-402a-ad1d-6ba29961deb0
Ferreira, Matheus V.
fe86b0ee-1b9b-434a-a83f-d5d3384fa223
Cunha, Joice Maria
7f0916f7-7358-4d9f-a090-3419ca179d4d
Oliveira, Kauê Marcel de
6e6809be-e385-4cec-9eca-fda945d7db17
Acco, Alexandra
0e2e0c54-f6ce-4fc6-a8c1-edaa46e512b2
Lopes, Maria Luiza C.
f8c960fa-7520-4999-a1e9-650c5ba6e3db
Couto Alves, Alexessander
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Valdameri, Glaucio
9f6c0a40-999f-4aca-88b4-59548425262a
Moure, Vivian R.
d32d33e5-df16-4c6d-9f9d-f4d474cb51fb
Picheth, Geraldo
83111b68-458e-49d9-ad5f-6096d4bf50f2
Manica, Graciele C.M.
d153bacc-bfa8-4ce6-901f-14ba455f80bc
Rego, Fabiane G.M.
28dc6fa5-ce01-4186-8490-d6008996b58a
11 April 2024
Lopes, Mateus S.
56c57601-183c-42c9-8c71-d619cffa2ebe
Baptistella, Gabriel B.
fed93f5f-fddd-4b55-ae90-6da552a507ee
Nunes, Giovana G.
eb346d2b-5f20-402a-ad1d-6ba29961deb0
Ferreira, Matheus V.
fe86b0ee-1b9b-434a-a83f-d5d3384fa223
Cunha, Joice Maria
7f0916f7-7358-4d9f-a090-3419ca179d4d
Oliveira, Kauê Marcel de
6e6809be-e385-4cec-9eca-fda945d7db17
Acco, Alexandra
0e2e0c54-f6ce-4fc6-a8c1-edaa46e512b2
Lopes, Maria Luiza C.
f8c960fa-7520-4999-a1e9-650c5ba6e3db
Couto Alves, Alexessander
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Valdameri, Glaucio
9f6c0a40-999f-4aca-88b4-59548425262a
Moure, Vivian R.
d32d33e5-df16-4c6d-9f9d-f4d474cb51fb
Picheth, Geraldo
83111b68-458e-49d9-ad5f-6096d4bf50f2
Manica, Graciele C.M.
d153bacc-bfa8-4ce6-901f-14ba455f80bc
Rego, Fabiane G.M.
28dc6fa5-ce01-4186-8490-d6008996b58a
Lopes, Mateus S., Baptistella, Gabriel B., Nunes, Giovana G., Ferreira, Matheus V., Cunha, Joice Maria, Oliveira, Kauê Marcel de, Acco, Alexandra, Lopes, Maria Luiza C., Couto Alves, Alexessander, Valdameri, Glaucio, Moure, Vivian R., Picheth, Geraldo, Manica, Graciele C.M. and Rego, Fabiane G.M.
(2024)
A non-toxic binuclear vanadium(IV) complex as insulin adjuvant improves the glycemic control in streptozotocin-induced diabetic rats.
Pharmaceuticals, 17 (4), [486].
(doi:10.3390/ph17040486).
Abstract
Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3NH)2[{VO(OH}2)(ox)2(µ–ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days. Vox2 at 100 mg/kg in association with insulin caused a 3.4 times decrease in blood glucose in STZ rats (424 mg/dL), reaching concentrations similar to those in the normoglycemic animals (126 mg/dL). Compared to insulin alone, the association with Vox2 caused an additional decrease in blood glucose of 39% and 65% at 30 and 100 mg/kg, respectively, and an increased pancreatic GSH levels 2.5 times. Vox2 alone did not cause gastrointestinal discomfort, diarrhea, and hepatic or renal toxicity and was not associated with changes in blood glucose level, lipid profile, or kidney or liver function. Our results highlight the potential of Vox2 in association with insulin in treating diabetes.
Text
pharmaceuticals-17-00486
- Version of Record
More information
Accepted/In Press date: 4 April 2024
Published date: 11 April 2024
Keywords:
adjunctive to insulin therapies, oxidovanadium(IV), STZ-induced diabetic rats, treatment efficacy, vanadium
Identifiers
Local EPrints ID: 509400
URI: http://eprints.soton.ac.uk/id/eprint/509400
ISSN: 1424-8247
PURE UUID: 3880f54c-6153-4e03-abed-a694a2789907
Catalogue record
Date deposited: 20 Feb 2026 17:38
Last modified: 21 Feb 2026 03:20
Export record
Altmetrics
Contributors
Author:
Mateus S. Lopes
Author:
Gabriel B. Baptistella
Author:
Giovana G. Nunes
Author:
Matheus V. Ferreira
Author:
Joice Maria Cunha
Author:
Kauê Marcel de Oliveira
Author:
Alexandra Acco
Author:
Maria Luiza C. Lopes
Author:
Alexessander Couto Alves
Author:
Glaucio Valdameri
Author:
Vivian R. Moure
Author:
Geraldo Picheth
Author:
Graciele C.M. Manica
Author:
Fabiane G.M. Rego
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics