Neonatal neurocritical care considerations for prenatally identified neurological disorders
Neonatal neurocritical care considerations for prenatally identified neurological disorders
With increased access to advanced prenatal neuroimaging and genetic testing, neurological disorders such as brain malformations, brain injuries, and genetic disorders, are increasingly being diagnosed during pregnancy. In this review, we address neonatal neurocritical care considerations for the population with prenatally identified neurological disorders. We identify antenatal considerations, including planning location of delivery, as well as postnatal considerations, including clinical phenotyping, neuromonitoring, neuroimaging, and genetic testing. The importance of interdisciplinary collaboration between obstetrics, maternal-fetal medicine, neonatology, pediatric neurology, neuroradiology, genetics, palliative care, early intervention and habilitative services is emphasized. We outline high-priority research gaps, and highlight the need for large, multicenter studies that capture diverse geographies, populations, care practices and settings longitudinally. Impact: Fetal neurology is a rapidly evolving field owing to the increased prenatal diagnosis of neurological disorders; however, the natural history of many fetal neurological disorders is not well known. We identify interdisciplinary neonatal neurocritical care considerations for newborns with prenatally diagnosed neurological disorders, such as neuroimaging, neuromonitoring, and family support. We outline high-priority research gaps in fetal neurology relevant to neurocritical care, including the need to prioritize large-scale longitudinal studies on the etiologies, short- and long-term outcomes of fetal neurologic disorders across diverse geographies and populations to improve counseling and care.
Gano, Dawn
eb85a6ee-76e9-4d37-ace4-136aaea39e7d
Boardman, James P.
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Agarwal, Sonika
1120990e-f05a-4bd8-8b8e-6a54f5d43a00
Newborn Brain Society Guidelines and Publications Committee
7 January 2026
Gano, Dawn
eb85a6ee-76e9-4d37-ace4-136aaea39e7d
Boardman, James P.
28ce9bba-1bff-40c3-968c-666d8a11b0dd
Agarwal, Sonika
1120990e-f05a-4bd8-8b8e-6a54f5d43a00
Gano, Dawn, Boardman, James P. and Agarwal, Sonika
,
et al. and Newborn Brain Society Guidelines and Publications Committee
(2026)
Neonatal neurocritical care considerations for prenatally identified neurological disorders.
Paediatric Research.
(doi:10.1038/s41390-025-04691-w).
Abstract
With increased access to advanced prenatal neuroimaging and genetic testing, neurological disorders such as brain malformations, brain injuries, and genetic disorders, are increasingly being diagnosed during pregnancy. In this review, we address neonatal neurocritical care considerations for the population with prenatally identified neurological disorders. We identify antenatal considerations, including planning location of delivery, as well as postnatal considerations, including clinical phenotyping, neuromonitoring, neuroimaging, and genetic testing. The importance of interdisciplinary collaboration between obstetrics, maternal-fetal medicine, neonatology, pediatric neurology, neuroradiology, genetics, palliative care, early intervention and habilitative services is emphasized. We outline high-priority research gaps, and highlight the need for large, multicenter studies that capture diverse geographies, populations, care practices and settings longitudinally. Impact: Fetal neurology is a rapidly evolving field owing to the increased prenatal diagnosis of neurological disorders; however, the natural history of many fetal neurological disorders is not well known. We identify interdisciplinary neonatal neurocritical care considerations for newborns with prenatally diagnosed neurological disorders, such as neuroimaging, neuromonitoring, and family support. We outline high-priority research gaps in fetal neurology relevant to neurocritical care, including the need to prioritize large-scale longitudinal studies on the etiologies, short- and long-term outcomes of fetal neurologic disorders across diverse geographies and populations to improve counseling and care.
Text
s41390-025-04691-w (1)
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Accepted/In Press date: 30 November 2025
e-pub ahead of print date: 7 January 2026
Published date: 7 January 2026
Identifiers
Local EPrints ID: 509448
URI: http://eprints.soton.ac.uk/id/eprint/509448
ISSN: 0031-3998
PURE UUID: b2bd0b8f-9429-4add-b2ba-b81a405dbd18
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Date deposited: 23 Feb 2026 17:46
Last modified: 23 Feb 2026 18:22
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Contributors
Author:
Dawn Gano
Author:
James P. Boardman
Author:
Sonika Agarwal
Author:
Brigitte Vollmer
Corporate Author: et al.
Corporate Author: Newborn Brain Society Guidelines and Publications Committee
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