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Acquisitions, inventors’ turnover, and innovation: evidence from the pharmaceutical industry

Acquisitions, inventors’ turnover, and innovation: evidence from the pharmaceutical industry
Acquisitions, inventors’ turnover, and innovation: evidence from the pharmaceutical industry
This paper examines the relationship between the post-merger decline in patenting among pharmaceutical firms, as observed in previous firm-level studies, and the following individual-level dynamics: (i) the exit of inventors from the innovation market, (ii) the departure of inventors from target firms to other research labs, and (iii) a decline in the innovative output of inventors who remain within the acquired firms. Using a large sample of target companies, we estimate that acquisitions are associated with an increase in exit rates of inventors between 7.6 and 17.5 percentage points and of their departure rates ranging from 12.2 to18.9 percentage points. We find similar results are obtained for large and small deals and that top inventors of targets are also more likely to exit or to leave when an acquisition takes place. Our results show that, for each inventor that exits the innovation market, around 2 patents are foregone, representing more than 30 percent loss of the expected output these scientists could have produced over their careers. Inventors who relocate to a different lab also generate 2 fewer patents compared to similar control scientists, representing a 30 percent decrease in their productivity too. Finally, inventors that stay at the acquired targets also experience a decrease in output of nearly one fewer patent. These results point to a significant decline in both human capital and consumer welfare, which call for a closer scrutiny of M&As.
Exit rates, Human capital loss, Innovation, Inventors, M&As, Patents, Separation rates
0014-2921
Ornaghi, Carmine
33275e47-4642-4023-a195-39c91d0146b0
Cassi, Lorenzo
d42b6540-254d-4b7a-9094-19e12e4ac657
Ornaghi, Carmine
33275e47-4642-4023-a195-39c91d0146b0
Cassi, Lorenzo
d42b6540-254d-4b7a-9094-19e12e4ac657

Ornaghi, Carmine and Cassi, Lorenzo (2026) Acquisitions, inventors’ turnover, and innovation: evidence from the pharmaceutical industry. European Economic Review, 184, [105263]. (doi:10.1016/j.euroecorev.2026.105263).

Record type: Article

Abstract

This paper examines the relationship between the post-merger decline in patenting among pharmaceutical firms, as observed in previous firm-level studies, and the following individual-level dynamics: (i) the exit of inventors from the innovation market, (ii) the departure of inventors from target firms to other research labs, and (iii) a decline in the innovative output of inventors who remain within the acquired firms. Using a large sample of target companies, we estimate that acquisitions are associated with an increase in exit rates of inventors between 7.6 and 17.5 percentage points and of their departure rates ranging from 12.2 to18.9 percentage points. We find similar results are obtained for large and small deals and that top inventors of targets are also more likely to exit or to leave when an acquisition takes place. Our results show that, for each inventor that exits the innovation market, around 2 patents are foregone, representing more than 30 percent loss of the expected output these scientists could have produced over their careers. Inventors who relocate to a different lab also generate 2 fewer patents compared to similar control scientists, representing a 30 percent decrease in their productivity too. Finally, inventors that stay at the acquired targets also experience a decrease in output of nearly one fewer patent. These results point to a significant decline in both human capital and consumer welfare, which call for a closer scrutiny of M&As.

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Accepted/In Press date: 18 January 2026
e-pub ahead of print date: 18 January 2026
Published date: 23 January 2026
Keywords: Exit rates, Human capital loss, Innovation, Inventors, M&As, Patents, Separation rates

Identifiers

Local EPrints ID: 509668
URI: http://eprints.soton.ac.uk/id/eprint/509668
ISSN: 0014-2921
PURE UUID: bf7a534b-f1f4-4809-90ca-f39b5c5461a1
ORCID for Carmine Ornaghi: ORCID iD orcid.org/0000-0003-2704-2537

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Date deposited: 02 Mar 2026 17:32
Last modified: 07 Mar 2026 02:58

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Contributors

Author: Carmine Ornaghi ORCID iD
Author: Lorenzo Cassi

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