READ ME File For "Beyond the synapse: Exploring CSP? s role in proteostasis, SNAP-25 stability, and cellular differentiation in PC12 cells"

DOI for dataset: https://doi.org/10.5258/SOTON/D3921
Date that the file was created: March,2026
ReadMe Author: Lucy Scullard, University of Southampton 0000-0002-5423-5003
Date of data collection: October 2020-July 2025
Information about geographic location of data collection: University of Southampton

This dataset supports the publication: Thesis
AUTHORS: Lucy Scullard, Vincent O Connor, Katrin Deinhardt
TITLE: Beyond the synapse: Exploring CSP? s role in proteostasis, SNAP-25 stability, and cellular differentiation in PC12 cells.
This dataset contains:

Description:
Two Excel files (Definite_E3_Ligase_List_with_synaptic_localisation and SNAP25_family_E3_ligase_protein_interactions_Bioinfomatics_investigation) containing bioinformatics data used for the analysis of chapter three of the thesis Beyond the synapse: Exploring CSP? s role in proteostasis, SNAP-25 stability, and cellular differentiation in PC12 cells (https://doi.org/10.52.58/01/T232).
File(Label_Free_Mass_spec_Protein_read_out_for_knockout_cells) with the mass spectroscopy readout of the proteins altered between PC12 parental and CSP-alpha knockout cells above a 2-fold change underpinning analysis of chapter 5 of the thesis Beyond the synapse: Exploring CSP? s role in proteostasis, SNAP-25 stability, and cellular differentiation in PC12 cells (https://doi.org/10.52.58/01/T232).
If data was derived from another source, list source:
List of protein interactions derived from BioGriD and UbiBrowser 
List of E3 ligases derived from the Human E3 ubiquitin ligases list from the National Institute of Health