Basal ganglia correlates of fatigue in young adults
Basal ganglia correlates of fatigue in young adults
Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.
Nakagawa, Seishu
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Takeuchi, Hikaru
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Taki, Yasuyuki
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Nouchi, Rui
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Kotozaki, Yuka
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Shinada, Takamitsu
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Maruyama, Tsukasa
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Sekiguchi, Atsushi
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Iizuka, Kunio
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Yokoyama, Ryoichi
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Yamamoto, Yuki
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Hanawa, Sugiko
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Araki, Tsuyoshi
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Miyauchi, Carlos Makoto
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Magistro, Daniele
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Sakaki, Kohei
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Jeong, Hyeonjeong
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Sasaki, Yukako
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Kawashima, Ryuta
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19 February 2016
Nakagawa, Seishu
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Takeuchi, Hikaru
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Taki, Yasuyuki
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Nouchi, Rui
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Kotozaki, Yuka
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Shinada, Takamitsu
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Maruyama, Tsukasa
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Sekiguchi, Atsushi
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Iizuka, Kunio
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Yokoyama, Ryoichi
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Yamamoto, Yuki
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Hanawa, Sugiko
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Araki, Tsuyoshi
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Miyauchi, Carlos Makoto
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Magistro, Daniele
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Sakaki, Kohei
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Jeong, Hyeonjeong
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Sasaki, Yukako
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Kawashima, Ryuta
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Nakagawa, Seishu, Takeuchi, Hikaru, Taki, Yasuyuki, Nouchi, Rui, Kotozaki, Yuka, Shinada, Takamitsu, Maruyama, Tsukasa, Sekiguchi, Atsushi, Iizuka, Kunio, Yokoyama, Ryoichi, Yamamoto, Yuki, Hanawa, Sugiko, Araki, Tsuyoshi, Miyauchi, Carlos Makoto, Magistro, Daniele, Sakaki, Kohei, Jeong, Hyeonjeong, Sasaki, Yukako and Kawashima, Ryuta
(2016)
Basal ganglia correlates of fatigue in young adults.
Scientific Reports, 6, [21386].
(doi:10.1038/srep21386).
Abstract
Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.
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srep21386
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Accepted/In Press date: 22 January 2016
Published date: 19 February 2016
Identifiers
Local EPrints ID: 510671
URI: http://eprints.soton.ac.uk/id/eprint/510671
ISSN: 2045-2322
PURE UUID: 76646e86-c3d7-4bdf-9a14-d76a0a9588d5
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Date deposited: 16 Apr 2026 16:37
Last modified: 17 Apr 2026 02:16
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Contributors
Author:
Seishu Nakagawa
Author:
Hikaru Takeuchi
Author:
Yasuyuki Taki
Author:
Rui Nouchi
Author:
Yuka Kotozaki
Author:
Takamitsu Shinada
Author:
Tsukasa Maruyama
Author:
Atsushi Sekiguchi
Author:
Kunio Iizuka
Author:
Ryoichi Yokoyama
Author:
Yuki Yamamoto
Author:
Sugiko Hanawa
Author:
Tsuyoshi Araki
Author:
Carlos Makoto Miyauchi
Author:
Daniele Magistro
Author:
Kohei Sakaki
Author:
Hyeonjeong Jeong
Author:
Yukako Sasaki
Author:
Ryuta Kawashima
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