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Novel fluorescent proteins for high-content screening

Record type: Article

The development of fast microscopic imaging devices has enabled the application of automated fluorescence microscopy to pharmaceutical high-throughput drug-discovery assays, referred to as high-content screening (HCS). Initially, green fluorescent protein and its derivatives from Aequorea Victoria, and later anthozoan fluorescent proteins (FPs) have become potent tools as live-cell markers in HCS assays. We illustrate the broad applicability of classic and novel FPs to drug-discovery assays, giving example applications of the use of FPs in multiplexed imaging as fluorescent timers, photosensitizers and pulse-chase labels, and for robotically integrated compound testing.

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Citation

Wolff, M., Wiedenmann, J., Nienhaus, G.U., Valler, M. and Heilker, R. (2006) Novel fluorescent proteins for high-content screening Drug Discovery Today, 11, (23-24), pp. 1054-1060. (doi:10.1016/j.drudis.2006.09.005).

More information

Published date: December 2006

Identifiers

Local EPrints ID: 51168
URI: http://eprints.soton.ac.uk/id/eprint/51168
ISSN: 1359-6446
PURE UUID: acd24cf2-3e9d-44d3-ae2f-882b696a5340
ORCID for J. Wiedenmann: ORCID iD orcid.org/0000-0003-2128-2943

Catalogue record

Date deposited: 08 May 2008
Last modified: 17 Jul 2017 14:49

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Contributors

Author: M. Wolff
Author: J. Wiedenmann ORCID iD
Author: G.U. Nienhaus
Author: M. Valler
Author: R. Heilker

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