Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte

Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2008) Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte. Sensors and Actuators B: Chemical, 131 (1), 323-332. (doi:10.1016/j.snb.2007.11.034).

Record type: Article

Abstract

New designs for microfluidic channels to be integrated with small-scale affinity sensors for analytical applications are provided. Theoretical approaches demonstrate efficient and uniform mass transfer of the analyte from the bulk flow to small-scale affinity sensors in the base of fluidic channels by (i) active control of the analyte flow speed over the affinity sensor, (ii) non-rectangular channel geometries and (iii) non-uniform distributions of recognition binding sites over the active area of the sensor. The methodology reported provides generic strategies that can be exploited for small-scale sensors in single or multiplex formats.

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Published date: 15 April 2008

Keywords: affinity sensor, microfluidics, mass transfer, laminar flow, biosensor, fluidic channel, detection, design optimisation, recognition molecule, analyte depletion

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