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Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte

Record type: Article

New designs for microfluidic channels to be integrated with small-scale affinity sensors for analytical applications are provided. Theoretical approaches demonstrate efficient and uniform mass transfer of the analyte from the bulk flow to small-scale affinity sensors in the base of fluidic channels by (i) active control of the analyte flow speed over the affinity sensor, (ii) non-rectangular channel geometries and (iii) non-uniform distributions of recognition binding sites over the active area of the sensor. The methodology reported provides generic strategies that can be exploited for small-scale sensors in single or multiplex formats.

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Citation

Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2008) Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte Sensors and Actuators B: Chemical, 131, (1), pp. 323-332. (doi:10.1016/j.snb.2007.11.034).

More information

Published date: 15 April 2008
Keywords: affinity sensor, microfluidics, mass transfer, laminar flow, biosensor, fluidic channel, detection, design optimisation, recognition molecule, analyte depletion

Identifiers

Local EPrints ID: 52038
URI: http://eprints.soton.ac.uk/id/eprint/52038
ISSN: 0925-4005
PURE UUID: 9998bc1b-5ca6-4ff1-abfa-41037830df5a

Catalogue record

Date deposited: 09 Jun 2008
Last modified: 17 Jul 2017 14:46

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