Friedrich, Daniel, Please, Colin P. and Melvin, Tracy
Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte
Sensors and Actuators B: Chemical, 131, (1), . (doi:10.1016/j.snb.2007.11.034).
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New designs for microfluidic channels to be integrated with small-scale affinity sensors for analytical applications are provided. Theoretical approaches demonstrate efficient and uniform mass transfer of the analyte from the bulk flow to small-scale affinity sensors in the base of fluidic channels by (i) active control of the analyte flow speed over the affinity sensor, (ii) non-rectangular channel geometries and (iii) non-uniform distributions of recognition binding sites over the active area of the sensor. The methodology reported provides generic strategies that can be exploited for small-scale sensors in single or multiplex formats.
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