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Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD

Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
Background
Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder.
Methods
To investigate the relationship between the dopamine transporter gene (SLC6A3) 3'-UTR VNTR genotypes and executive function in children with ADHD, 196 children diagnosed with ADHD were sequentially recruited, genotyped, and tested using a battery of three neuropsychological tests aimed at assessing the different aspects of executive functioning. Results: Taking into account a correction for multiple comparisons, the main finding of this study is a significant genotype effect on TOL (F = 6.902, p = 0.009) and FFDI performances (F = 7.125, p = 0.008) as well as strong trends on SOPT error scores (F = 4,996 p = 0.026) and Digit Span performance (F = 6.28, p = 0.023). Children with the 9/10 genotype had poorer performance on all four measures compared to children with the 10/10 genotype. No effect of genotype on WCST measures of performance was detected.
Conclusion
Results are compatible with the view that SLC6A3 genotype may modulate components of executive function performance in children with ADHD.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
1471-244X
45
Karama, Sherif
d13f2472-487a-42c0-bc08-40b17e717f29
Grizenko, Natalie
4236617e-b078-4d2c-8f7f-fc5adae3d772
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Doyle, Alysa
5229db16-6c92-49c2-87f4-796f71a665e9
Biederman, Joseph
fa82c04e-61be-40f5-824b-a5920ed3c9ed
Mbekou, Valentin
fdc9b4fb-4977-4f5c-8e6e-ee221cc33d2b
Polotskaia, Anna
37cec089-2360-4e86-9f54-f35afb639cbd
Ter-Stepanian, Marina
6c26ec13-c94b-4971-8e53-b2ea532088fa
De Guzman, Rosherrie
4d54f92c-449f-49f0-9a31-c24e809a62b3
Bellingham, Johanne
527c7c20-2dcc-4c2d-b16b-24ec87a81913
Sengupta, Sarojini
cd630209-1c0f-4e0b-b9c9-3ccdafd92a5c
Joober, Ridha
cab1bd50-8e23-4c88-b1e3-c80ee5ca10d1
Karama, Sherif
d13f2472-487a-42c0-bc08-40b17e717f29
Grizenko, Natalie
4236617e-b078-4d2c-8f7f-fc5adae3d772
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Doyle, Alysa
5229db16-6c92-49c2-87f4-796f71a665e9
Biederman, Joseph
fa82c04e-61be-40f5-824b-a5920ed3c9ed
Mbekou, Valentin
fdc9b4fb-4977-4f5c-8e6e-ee221cc33d2b
Polotskaia, Anna
37cec089-2360-4e86-9f54-f35afb639cbd
Ter-Stepanian, Marina
6c26ec13-c94b-4971-8e53-b2ea532088fa
De Guzman, Rosherrie
4d54f92c-449f-49f0-9a31-c24e809a62b3
Bellingham, Johanne
527c7c20-2dcc-4c2d-b16b-24ec87a81913
Sengupta, Sarojini
cd630209-1c0f-4e0b-b9c9-3ccdafd92a5c
Joober, Ridha
cab1bd50-8e23-4c88-b1e3-c80ee5ca10d1

Karama, Sherif, Grizenko, Natalie, Sonuga-Barke, Edmund, Doyle, Alysa, Biederman, Joseph, Mbekou, Valentin, Polotskaia, Anna, Ter-Stepanian, Marina, De Guzman, Rosherrie, Bellingham, Johanne, Sengupta, Sarojini and Joober, Ridha (2008) Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD. BMC Psychiatry, 8 (Suppl 1), 45. (doi:10.1186/1471-244X-8-45).

Record type: Article

Abstract

Background
Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder.
Methods
To investigate the relationship between the dopamine transporter gene (SLC6A3) 3'-UTR VNTR genotypes and executive function in children with ADHD, 196 children diagnosed with ADHD were sequentially recruited, genotyped, and tested using a battery of three neuropsychological tests aimed at assessing the different aspects of executive functioning. Results: Taking into account a correction for multiple comparisons, the main finding of this study is a significant genotype effect on TOL (F = 6.902, p = 0.009) and FFDI performances (F = 7.125, p = 0.008) as well as strong trends on SOPT error scores (F = 4,996 p = 0.026) and Digit Span performance (F = 6.28, p = 0.023). Children with the 9/10 genotype had poorer performance on all four measures compared to children with the 10/10 genotype. No effect of genotype on WCST measures of performance was detected.
Conclusion
Results are compatible with the view that SLC6A3 genotype may modulate components of executive function performance in children with ADHD.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

This record has no associated files available for download.

More information

Published date: 17 June 2008

Identifiers

Local EPrints ID: 52083
URI: http://eprints.soton.ac.uk/id/eprint/52083
ISSN: 1471-244X
PURE UUID: 38ad1508-bddf-446a-a250-d61906ae7f8b

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Date deposited: 18 Jun 2008
Last modified: 15 Mar 2024 10:22

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Contributors

Author: Sherif Karama
Author: Natalie Grizenko
Author: Edmund Sonuga-Barke
Author: Alysa Doyle
Author: Joseph Biederman
Author: Valentin Mbekou
Author: Anna Polotskaia
Author: Marina Ter-Stepanian
Author: Rosherrie De Guzman
Author: Johanne Bellingham
Author: Sarojini Sengupta
Author: Ridha Joober

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