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Allostatic load, perceived stress, and health: a prospective study in two age groups. [in issue: Biobehavioral Stress Response Protective and Damaging Effects]

Record type: Article

Overactivity of the hypothalamus-pituitary-adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress-related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1-year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.

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Citation

Hellhammer, J., Schlotz, W., Stone, A.A., Pirke, K.M. and Hellhammer, D. (2004) Allostatic load, perceived stress, and health: a prospective study in two age groups. [in issue: Biobehavioral Stress Response Protective and Damaging Effects] Annals of the New York Academy of Sciences, 1032, pp. 8-13. (doi:10.1196/annals.1314.002).

More information

Published date: 2004
Keywords: cortisol, allostatic load, protective and damaging effects, hypocortisolism, chronic stress, health, fibrinogen, whr

Identifiers

Local EPrints ID: 52579
URI: http://eprints.soton.ac.uk/id/eprint/52579
ISSN: 0077-8923
PURE UUID: 2b846a84-7bec-4c89-9475-38a06bad5d5d

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Date deposited: 10 Jul 2008
Last modified: 17 Jul 2017 14:40

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Contributors

Author: J. Hellhammer
Author: W. Schlotz
Author: A.A. Stone
Author: K.M. Pirke
Author: D. Hellhammer

University divisions


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