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The synthesis of a combretastatin A-4 based library and discovery of new cooperative ortho-effects in Wittig reactions leading to (Z)-stilbenes

The synthesis of a combretastatin A-4 based library and discovery of new cooperative ortho-effects in Wittig reactions leading to (Z)-stilbenes
The synthesis of a combretastatin A-4 based library and discovery of new cooperative ortho-effects in Wittig reactions leading to (Z)-stilbenes
A synthesis of combretastatin A-4 and a small library of analogues led to the discovery of some new cooperative ortho-­effects allowing (Z)-stilbenes to be prepared in high yield and dia­stereomeric ratio.
phenanthrene, derivatives, stereoselective synthesis, wittig reactions, substituted benzaldehydes, anticancer agents, antitumor agents, stilbene, alkenes, total synthesis, stereoselectivity
0936-5214
2977-2980
Harrowven, D.C.
bddcfab6-dbde-49df-aec2-42abbcf5d10b
Guy, I.L.
c867bfd7-2745-4810-b90f-1dd4d1c67056
Howell, M.
dfc9bbda-0aa8-417c-8b3b-5ca605ff5891
Packham, G.
86855c5b-6b61-4367-b14b-c2fc2ba2ed11
Harrowven, D.C.
bddcfab6-dbde-49df-aec2-42abbcf5d10b
Guy, I.L.
c867bfd7-2745-4810-b90f-1dd4d1c67056
Howell, M.
dfc9bbda-0aa8-417c-8b3b-5ca605ff5891
Packham, G.
86855c5b-6b61-4367-b14b-c2fc2ba2ed11

Harrowven, D.C., Guy, I.L., Howell, M. and Packham, G. (2006) The synthesis of a combretastatin A-4 based library and discovery of new cooperative ortho-effects in Wittig reactions leading to (Z)-stilbenes. Synlett, (18), 2977-2980. (doi:10.1055/s-2006-948200).

Record type: Article

Abstract

A synthesis of combretastatin A-4 and a small library of analogues led to the discovery of some new cooperative ortho-­effects allowing (Z)-stilbenes to be prepared in high yield and dia­stereomeric ratio.

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More information

Published date: 2006
Keywords: phenanthrene, derivatives, stereoselective synthesis, wittig reactions, substituted benzaldehydes, anticancer agents, antitumor agents, stilbene, alkenes, total synthesis, stereoselectivity
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Identifiers

Local EPrints ID: 54209
URI: http://eprints.soton.ac.uk/id/eprint/54209
DOI: doi:10.1055/s-2006-948200
ISSN: 0936-5214
PURE UUID: 8b61bb96-f0f0-42e7-bffd-66c6ff29662d
ORCID for D.C. Harrowven: ORCID iD orcid.org/0000-0001-6730-3573

Catalogue record

Date deposited: 31 Jul 2008
Last modified: 16 Mar 2024 02:46

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Contributors

Author: D.C. Harrowven ORCID iD
Author: I.L. Guy
Author: M. Howell
Author: G. Packham

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