Zirconium-mediated synthesis of azepanes and benzazepanes
Zirconium-mediated synthesis of azepanes and benzazepanes
Intramolecular co-cyclisation of 4- or 5-azanona-1,8-dienes, -enynes and -diynes using zirconocene(1-butene) gives zirconacycles which may be protonated to afford 3,4- or 4,5-disubstituted azepanes or, for the diyne derived systems, reacted with dimethyl acetylenedicarboxylate and CuCl to afford 2- or 3-benzazepanes.
zirconacyclopentadienes, benzazepanes, receptor, analogs, azepanes, alkynes, promoted, cyclization, carbonylation, 4-disubstituted piperidines, metallacycles, heterocycles, 3, reduced isoquinolines, benzene-derivatives, zirconium
3439-3442
Macfarlane, Donald P.S.
321775c5-d95d-4831-b5d9-534463c45185
Norton, David
4c63fcf9-0fc8-4623-b414-443d4658bbed
Whitby, Richard J.
45632236-ab00-4ad0-a02d-6209043e818b
Tupper, David
e5c65499-83aa-44c3-bda9-1d49d6ef7525
December 2006
Macfarlane, Donald P.S.
321775c5-d95d-4831-b5d9-534463c45185
Norton, David
4c63fcf9-0fc8-4623-b414-443d4658bbed
Whitby, Richard J.
45632236-ab00-4ad0-a02d-6209043e818b
Tupper, David
e5c65499-83aa-44c3-bda9-1d49d6ef7525
Macfarlane, Donald P.S., Norton, David, Whitby, Richard J. and Tupper, David
(2006)
Zirconium-mediated synthesis of azepanes and benzazepanes.
Synlett, (20), .
(doi:10.1055/s-2006-956477).
Abstract
Intramolecular co-cyclisation of 4- or 5-azanona-1,8-dienes, -enynes and -diynes using zirconocene(1-butene) gives zirconacycles which may be protonated to afford 3,4- or 4,5-disubstituted azepanes or, for the diyne derived systems, reacted with dimethyl acetylenedicarboxylate and CuCl to afford 2- or 3-benzazepanes.
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Published date: December 2006
Keywords:
zirconacyclopentadienes, benzazepanes, receptor, analogs, azepanes, alkynes, promoted, cyclization, carbonylation, 4-disubstituted piperidines, metallacycles, heterocycles, 3, reduced isoquinolines, benzene-derivatives, zirconium
Identifiers
Local EPrints ID: 54218
URI: http://eprints.soton.ac.uk/id/eprint/54218
ISSN: 0936-5214
PURE UUID: 7c24e14c-afa2-4099-9c7c-5db29e1863a5
Catalogue record
Date deposited: 29 Jul 2008
Last modified: 16 Mar 2024 02:33
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Contributors
Author:
Donald P.S. Macfarlane
Author:
David Norton
Author:
David Tupper
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