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Synthesis of enantiopure 4-(dihydroxyalkyl)-beta-lactams from D-mannitol using Ley's BDA-protected L-glyceraldehyde

Synthesis of enantiopure 4-(dihydroxyalkyl)-beta-lactams from D-mannitol using Ley's BDA-protected L-glyceraldehyde
Synthesis of enantiopure 4-(dihydroxyalkyl)-beta-lactams from D-mannitol using Ley's BDA-protected L-glyceraldehyde
Enantiomerically pure ethylene glycol derived ?-lactams have been synthesized from Ley's BDA-protected l-glyceraldehyde imines via Staudinger reaction followed by deprotection.
beta-lactams, staudinger reaction, stereoselective synthesis, chiral, auxiliaries, protected glyceraldehydes
0936-5214
3180-3182
Areces, P.
e88f0d0f-33ff-4e7a-8839-c6237abf795e
Carrasco, E.
2351eaf8-a83e-476f-99fc-a3601ec5949c
Light, M.E.
cf57314e-6856-491b-a8d2-2dffc452e161
Santos, M.
c9dd55b5-bbc5-4ce3-ac08-61d95ea98007
Plumet, J.
9709c2cf-1cd0-4ba0-b982-a18212bb560f
Areces, P.
e88f0d0f-33ff-4e7a-8839-c6237abf795e
Carrasco, E.
2351eaf8-a83e-476f-99fc-a3601ec5949c
Light, M.E.
cf57314e-6856-491b-a8d2-2dffc452e161
Santos, M.
c9dd55b5-bbc5-4ce3-ac08-61d95ea98007
Plumet, J.
9709c2cf-1cd0-4ba0-b982-a18212bb560f

Areces, P., Carrasco, E., Light, M.E., Santos, M. and Plumet, J. (2007) Synthesis of enantiopure 4-(dihydroxyalkyl)-beta-lactams from D-mannitol using Ley's BDA-protected L-glyceraldehyde. Synlett, (20), 3180-3182. (doi:10.1055/s-2007-992375).

Record type: Article

Abstract

Enantiomerically pure ethylene glycol derived ?-lactams have been synthesized from Ley's BDA-protected l-glyceraldehyde imines via Staudinger reaction followed by deprotection.

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More information

Published date: 2007
Keywords: beta-lactams, staudinger reaction, stereoselective synthesis, chiral, auxiliaries, protected glyceraldehydes
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Identifiers

Local EPrints ID: 54236
URI: http://eprints.soton.ac.uk/id/eprint/54236
DOI: doi:10.1055/s-2007-992375
ISSN: 0936-5214
PURE UUID: d4e3c4b8-327a-4a8d-b589-2e851ca5aad4
ORCID for M.E. Light: ORCID iD orcid.org/0000-0002-0585-0843

Catalogue record

Date deposited: 31 Jul 2008
Last modified: 16 Mar 2024 03:04

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Contributors

Author: P. Areces
Author: E. Carrasco
Author: M.E. Light ORCID iD
Author: M. Santos
Author: J. Plumet

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