Tandem Michael/Michael reactions mediated by phosphines or aryl thiolates
Tandem Michael/Michael reactions mediated by phosphines or aryl thiolates
Tri-n-butyl phosphine was found to effect tandem Michael/Michael cyclisations leading to the formation of cyclopentenes and cyclohexenes in good yields, whilst p-TolSH in conjunction with a catalytic amount of p-TolSNa effected cyclisation to the corresponding cyclopentanes and cyclohexanes.
phosphines, cyclizations, tandem reactions, aldol reactions, baylis-hillman-reaction, asymmetric-synthesis, michael additions, secondary-amines, conjugate addition, nucleophile, cycloalkenes, nitrogen, bis-enones
1100-1106
Brown, Paul M.
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Käppel, Nina
b3c714f8-5e10-42af-8c85-47c4a16e0823
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
29 January 2007
Brown, Paul M.
2b2dba2e-50be-4798-add3-4555bfd630ff
Käppel, Nina
b3c714f8-5e10-42af-8c85-47c4a16e0823
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Brown, Paul M., Käppel, Nina, Murphy, Patrick J., Coles, Simon J. and Hursthouse, Michael B.
(2007)
Tandem Michael/Michael reactions mediated by phosphines or aryl thiolates.
Tetrahedron, 63 (5), .
(doi:10.1016/j.tet.2006.11.064).
Abstract
Tri-n-butyl phosphine was found to effect tandem Michael/Michael cyclisations leading to the formation of cyclopentenes and cyclohexenes in good yields, whilst p-TolSH in conjunction with a catalytic amount of p-TolSNa effected cyclisation to the corresponding cyclopentanes and cyclohexanes.
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Published date: 29 January 2007
Keywords:
phosphines, cyclizations, tandem reactions, aldol reactions, baylis-hillman-reaction, asymmetric-synthesis, michael additions, secondary-amines, conjugate addition, nucleophile, cycloalkenes, nitrogen, bis-enones
Identifiers
Local EPrints ID: 54257
URI: http://eprints.soton.ac.uk/id/eprint/54257
ISSN: 0040-4020
PURE UUID: 87e3a30f-c74e-4b63-9a6c-80a222012ab2
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Date deposited: 31 Jul 2008
Last modified: 16 Mar 2024 03:05
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Contributors
Author:
Paul M. Brown
Author:
Nina Käppel
Author:
Patrick J. Murphy
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