Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material


Cavalli, G., Banu, S., Ranasinghe, R.T., Broder, G.R., Martins, H.F.P., Neylon, C., Morgan, H., Bradley, M. and Roach, P.L. (2007) Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material Journal of Combinatorial Chemistry, 9, (3), pp. 462-472. (doi:10.1021/cc060079p).

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Description/Abstract

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/cc060079p
ISSNs: 1520-4766 (print)
Keywords: photoresist, oligonucleotides, immobilization, capillary-electrophoresis, high-aspect-ratio, archip epoxy, mass-spectrometry, peptide-synthesis, protease inhibitors, mems
Subjects:
ePrint ID: 54261
Date :
Date Event
2007Published
Date Deposited: 31 Jul 2008
Last Modified: 16 Apr 2017 17:47
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/54261

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