Regioselective synthesis of 4 '-amino-1 ' H-spiro[cyclohexane-1,2 '-(pyrimido [1,2-albenzimidazole)]-3 '-carbonitrile in aqueous medium

Dandia, A., Sarawgi, P., Bingham, A.L., Drake, J.E., Hursthouse, M.B., Light, M.E. and Ratnani, R. (2007) Regioselective synthesis of 4 '-amino-1 ' H-spiro[cyclohexane-1,2 '-(pyrimido [1,2-albenzimidazole)]-3 '-carbonitrile in aqueous medium Journal of Chemical Research, S, (3), pp. 155-159. (doi:10.3184/030823407X198582).


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A simple, mild and environment-friendly procedure for synthesis of 4'-amino-1'H-spiro[cyclohexane-1,2'-(pyrimido[1,2-a]benzimidazole)]-3'-carbonitrile is developed using microwave irradiation in water. The product is obtained in short time, in excellent yield, and in a good state of purity. The reaction pathway and the influence of reaction conditions on regiochemistry are also investigated. The regioselectivity in this process is confirmed chemically and by single-crystal X-ray molecular structure determination.

Item Type: Article
Digital Object Identifier (DOI): doi:10.3184/030823407X198582
ISSNs: 0308-2342 (print)
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Keywords: fused pyrimidines, aqueous media, benzimidazoles, 2-aminobenzimidazole derivatives, biological importance, crystal-structure, synthesis, green chemical-synthesis, microwave irradiation, heterocyclic, part 5, combinatorial library, efficient, one-pot synthesis
ePrint ID: 54277
Date :
Date Event
Date Deposited: 31 Jul 2008
Last Modified: 16 Apr 2017 17:47
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