The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer

Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer
Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer
Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.
cholesterol, nonotechnology, dna, fluorescence melting, self-assembly
1525-7770
785-794
Durand, Adeline
9eef6a77-9477-405d-a8e2-e0237b52c412
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Durand, Adeline
9eef6a77-9477-405d-a8e2-e0237b52c412
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89

Durand, Adeline and Brown, Tom (2007) Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer. Nucleosides, Nucleotides & Nucleic Acids, 26 (6 & 7), 785-794. (doi:10.1080/15257770701501534).

Record type: Article

Abstract

Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.

This record has no associated files available for download.

More information

Published date: June 2007
Keywords: cholesterol, nonotechnology, dna, fluorescence melting, self-assembly
Learn more about Chemistry research

Identifiers

Local EPrints ID: 54287
URI: http://eprints.soton.ac.uk/id/eprint/54287
DOI: doi:10.1080/15257770701501534
ISSN: 1525-7770
PURE UUID: 9f2f6ab6-ae64-4aa7-972e-acdaa93413ce

Catalogue record

Date deposited: 30 Jul 2008
Last modified: 15 Mar 2024 10:46

Export record

Altmetrics

Contributors

Author: Adeline Durand
Author: Tom Brown

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×