CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues
CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues
Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.
triple helices, cg recognition, triplex, fluorescence melting, uv melting
1363-1367
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Natarajan, Srinivasan
c6cba2d6-f604-40da-bf5f-cc26c3ab0215
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
October 2007
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Natarajan, Srinivasan
c6cba2d6-f604-40da-bf5f-cc26c3ab0215
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Gerrard, Simon R., Natarajan, Srinivasan, Fox, Keith R. and Brown, Tom
(2007)
CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Nucleosides, Nucleotides & Nucleic Acids, 26 (10-12), .
(doi:10.1080/15257770701533958).
Abstract
Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.
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Published date: October 2007
Keywords:
triple helices, cg recognition, triplex, fluorescence melting, uv melting
Identifiers
Local EPrints ID: 54302
URI: http://eprints.soton.ac.uk/id/eprint/54302
ISSN: 1525-7770
PURE UUID: a901784b-d4ad-4991-8d45-79498a9c322d
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Date deposited: 30 Jul 2008
Last modified: 16 Mar 2024 02:36
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Author:
Simon R. Gerrard
Author:
Srinivasan Natarajan
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