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Synthesis of anthraquinone oligonucleotides for triplex stabilization

Synthesis of anthraquinone oligonucleotides for triplex stabilization
Synthesis of anthraquinone oligonucleotides for triplex stabilization
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.
anthraquinone, triplex stabilizers, fluorescence quenchers
1525-7770
921-925
Zhao, Zhengyun
fdc7f812-c529-4680-8fe2-fdb0e6fc134e
Peng, Guomei
815906fe-23a8-43aa-a1d0-316dff95369a
Michels, Jan
103ae3a3-dbd3-4c9d-bbd8-f1c49dff53bc
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Zhao, Zhengyun
fdc7f812-c529-4680-8fe2-fdb0e6fc134e
Peng, Guomei
815906fe-23a8-43aa-a1d0-316dff95369a
Michels, Jan
103ae3a3-dbd3-4c9d-bbd8-f1c49dff53bc
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89

Zhao, Zhengyun, Peng, Guomei, Michels, Jan, Fox, Keith R. and Brown, Tom (2007) Synthesis of anthraquinone oligonucleotides for triplex stabilization. Nucleosides, Nucleotides & Nucleic Acids, 26 (8 & 9), 921-925. (doi:10.1080/15257770701506491).

Record type: Article

Abstract

The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.

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More information

Published date: August 2007
Keywords: anthraquinone, triplex stabilizers, fluorescence quenchers
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Identifiers

Local EPrints ID: 54411
URI: http://eprints.soton.ac.uk/id/eprint/54411
DOI: doi:10.1080/15257770701506491
ISSN: 1525-7770
PURE UUID: f0642ab5-c7e6-469a-97e2-89e64f61f688
ORCID for Keith R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 30 Jul 2008
Last modified: 16 Mar 2024 02:36

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Contributors

Author: Zhengyun Zhao
Author: Guomei Peng
Author: Jan Michels
Author: Keith R. Fox ORCID iD
Author: Tom Brown

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