Zhao, Zhengyun, Peng, Guomei, Michels, Jan, Fox, Keith R. and Brown, Tom
Synthesis of anthraquinone oligonucleotides for triplex stabilization
Nucleosides, Nucleotides & Nucleic Acids, 26, (8 & 9), . (doi:10.1080/15257770701506491).
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The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.
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