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Integrative feedback and robustness in a lipid biosynthetic network

Integrative feedback and robustness in a lipid biosynthetic network
Integrative feedback and robustness in a lipid biosynthetic network
The homeostatic control of membrane lipid composition appears to be of central importance for cell functioning and survival. However, while lipid biosynthetic reaction networks have been mapped in detail, the underlying control architecture which underpins these networks remains elusive. A key problem in determining the control architectures of lipid biosynthetic pathways, and the mechanisms through which control is achieved, is that the compositional complexity of lipid membranes makes it difficult to determine which membrane parameter is under homeostatic control. Recently, we reported that membrane stored elastic energy provides a physical feedback signal which modulates the activity in vitro of CTP:phosphocholine cytidylyltransferase (CCT), an extrinsic membrane enzyme which catalyses a key step in the synthesis of phosphatidylcholine lipids in the Kennedy pathway (Kennedy 1953 J. Am. Chem. Soc. 75, 249–250). We postulate that stored elastic energy may be the main property of membranes that is under homeostatic control. Here we report the results of simulations based on this postulate, which reveal a possible control architecture for lipid biosynthesis networks in vivo.
dependence, membrane torque, phosphoethanolamine, model, binding, cytidylyltransferase, vesicles, stored elastic energy, activation, diacylglycerol, curvature, tension, pathways, networks, ctp-phosphocholine cytidylyltransferase, homeostasis, simulation, packing
1742-5689
533-543
Beard, Jason
5806cfcb-ef83-4729-947b-8ad167d37abc
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36
Cheetham, Matthew J.
a59834f9-bbd3-49b2-9a00-5e9b851b635e
Beard, Jason
5806cfcb-ef83-4729-947b-8ad167d37abc
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36
Cheetham, Matthew J.
a59834f9-bbd3-49b2-9a00-5e9b851b635e

Beard, Jason, Attard, George S. and Cheetham, Matthew J. (2008) Integrative feedback and robustness in a lipid biosynthetic network. Journal of the Royal Society Interface, 5 (22), 533-543. (doi:10.1098/rsif.2007.1155).

Record type: Article

Abstract

The homeostatic control of membrane lipid composition appears to be of central importance for cell functioning and survival. However, while lipid biosynthetic reaction networks have been mapped in detail, the underlying control architecture which underpins these networks remains elusive. A key problem in determining the control architectures of lipid biosynthetic pathways, and the mechanisms through which control is achieved, is that the compositional complexity of lipid membranes makes it difficult to determine which membrane parameter is under homeostatic control. Recently, we reported that membrane stored elastic energy provides a physical feedback signal which modulates the activity in vitro of CTP:phosphocholine cytidylyltransferase (CCT), an extrinsic membrane enzyme which catalyses a key step in the synthesis of phosphatidylcholine lipids in the Kennedy pathway (Kennedy 1953 J. Am. Chem. Soc. 75, 249–250). We postulate that stored elastic energy may be the main property of membranes that is under homeostatic control. Here we report the results of simulations based on this postulate, which reveal a possible control architecture for lipid biosynthesis networks in vivo.

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More information

e-pub ahead of print date: 16 October 2007
Published date: May 2008
Keywords: dependence, membrane torque, phosphoethanolamine, model, binding, cytidylyltransferase, vesicles, stored elastic energy, activation, diacylglycerol, curvature, tension, pathways, networks, ctp-phosphocholine cytidylyltransferase, homeostasis, simulation, packing

Identifiers

Local EPrints ID: 54422
URI: https://eprints.soton.ac.uk/id/eprint/54422
ISSN: 1742-5689
PURE UUID: ee14d814-7b64-4a5f-b0a7-cdbc99f18c4d
ORCID for George S. Attard: ORCID iD orcid.org/0000-0001-8304-0742

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 20 Jul 2019 01:21

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