Relaxation and Simplex mathematical algorithms applied to the study of steady-state electrochemical responses of immobilized enzyme biosensors: comparison with experiments
Relaxation and Simplex mathematical algorithms applied to the study of steady-state electrochemical responses of immobilized enzyme biosensors: comparison with experiments
A description of the implementation of the relaxation method with automatic mesh point allocation for immobilized enzyme electrodes is presented. The advantages of this method for the solution of coupled reaction–diffusion problems are discussed. The relaxation numerical simulation technique is combined with the Simplex fitting algorithm to extract kinetic parameters from experimental data. The results of the simulations are compared to experimental data from self-assembled multilayered electrodes comprised of glucose oxidase (GOx) and an Os modified redox mediator and found to be in excellent agreement.
electrostatic self-assembly, enzyme electrodes, relaxation method, simplex algorithm
87-98
Flexer, V.
da447235-0802-405a-876a-02d918abf2ab
Pratt, K.F.E.
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Garay, F.
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Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Calvo, E.J.
e6eb516d-41a2-4da7-aecd-9605a2483ce6
May 2008
Flexer, V.
da447235-0802-405a-876a-02d918abf2ab
Pratt, K.F.E.
0a2c16a5-b8d6-419a-982f-fc2c43c55320
Garay, F.
7c288c93-cf06-420d-b4ca-8d86d00fe3a7
Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Calvo, E.J.
e6eb516d-41a2-4da7-aecd-9605a2483ce6
Flexer, V., Pratt, K.F.E., Garay, F., Bartlett, P.N. and Calvo, E.J.
(2008)
Relaxation and Simplex mathematical algorithms applied to the study of steady-state electrochemical responses of immobilized enzyme biosensors: comparison with experiments.
Journal of Electroanalytical Chemistry, 616 (1-2), .
(doi:10.1016/j.jelechem.2008.01.006).
Abstract
A description of the implementation of the relaxation method with automatic mesh point allocation for immobilized enzyme electrodes is presented. The advantages of this method for the solution of coupled reaction–diffusion problems are discussed. The relaxation numerical simulation technique is combined with the Simplex fitting algorithm to extract kinetic parameters from experimental data. The results of the simulations are compared to experimental data from self-assembled multilayered electrodes comprised of glucose oxidase (GOx) and an Os modified redox mediator and found to be in excellent agreement.
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Published date: May 2008
Keywords:
electrostatic self-assembly, enzyme electrodes, relaxation method, simplex algorithm
Identifiers
Local EPrints ID: 54451
URI: http://eprints.soton.ac.uk/id/eprint/54451
ISSN: 1572-6657
PURE UUID: ee903527-3269-4320-aca8-9ea216fbccab
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Date deposited: 06 Aug 2008
Last modified: 16 Mar 2024 02:43
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Contributors
Author:
V. Flexer
Author:
K.F.E. Pratt
Author:
F. Garay
Author:
E.J. Calvo
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